The Role of Oral Hygiene in Head and Neck Cancer: Results from International Head and Neck Cancer Epidemiology (INHANCE) Consortium

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Citation

Hashim, Dana; Sartori, Samantha; Brennan, Paul; Curado, Maria Paula; Wunsch-Filho, Victor; Divaris, Kimon; Olshan, Andrew F.; Zevallos, Jose P.; Winn, Deborah M.; & Franceschi, Silvia, et al. (2016). The Role of Oral Hygiene in Head and Neck Cancer: Results from International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Annals of Oncology, 27(8), 1619-1625. PMCID: PMC4959929

Abstract

BACKGROUND: Poor oral hygiene has been proposed to contribute to head and neck cancer (HNC) risk, although causality and independency of some indicators are uncertain. This study investigates the relationship of five oral hygiene indicators with incident HNCs.
METHODS: In a pooled analysis of 8925 HNC cases and 12 527 controls from 13 studies participating in the International Head and Neck Cancer Epidemiology Consortium, comparable data on good oral hygiene indicators were harmonized. These included: no denture wear, no gum disease (or bleeding), <5 missing teeth, tooth brushing at least daily, and visiting a dentist >/=once a year. Logistic regression was used to estimate the effects of each oral hygiene indicator and cumulative score on HNC risk, adjusting for tobacco smoking and alcohol consumption.
RESULTS: Inverse associations with any HNC, in the hypothesized direction, were observed for <5 missing teeth [odds ratio (OR) = 0.78; 95% confidence interval (CI) 0.74, 0.82], annual dentist visit (OR = 0.82; 95% CI 0.78, 0.87), daily tooth brushing (OR = 0.83, 95% CI 0.79, 0.88), and no gum disease (OR = 0.94; 95% CI 0.89, 0.99), and no association was observed for wearing dentures. These associations were relatively consistent across specific cancer sites, especially for tooth brushing and dentist visits. The population attributable fraction for CONCLUSION: Good oral hygiene, as characterized by few missing teeth, annual dentist visits, and daily tooth brushing, may modestly reduce the risk of HNC.

URL

http://dx.doi.org/10.1093/annonc/mdw224

Reference Type

Journal Article

Year Published

2016

Journal Title

Annals of Oncology

Author(s)

Hashim, Dana
Sartori, Samantha
Brennan, Paul
Curado, Maria Paula
Wunsch-Filho, Victor
Divaris, Kimon
Olshan, Andrew F.
Zevallos, Jose P.
Winn, Deborah M.
Franceschi, Silvia
Castellsague, Xavier
Lissowska, Jolanta
Rudnai, Peter
Matsuo, Keitaro
Morgenstern, Hal
Chen, Chu
Vaughan, Thomas L.
Hofmann, Jonathan N.
D'Souza, Gypsyamber
Haddad, Robert I.
Wu, Hongyu
Lee, Yuan-Chin Amy
Hashibe, Mia
La Vecchia, Carlo
Boffetta, Paolo

PMCID

PMC4959929

ORCiD

Olshan - 0000-0001-9115-5128