The Association of Diabetes and Obesity with Prostate Cancer Aggressiveness among Black Americans and White Americans in a Population-Based Study

Citation

Khan, Saira; Cai, Jianwen; Nielsen, Matthew E.; Troester, Melissa A.; Mohler, James L.; Fontham, Elizabeth T. H.; Hendrix, Laura H.; Farnan, Laura; Olshan, Andrew F.; & Bensen, Jeannette T. (2016). The Association of Diabetes and Obesity with Prostate Cancer Aggressiveness among Black Americans and White Americans in a Population-Based Study. Cancer Causes & Control, 27(12), 1475-1485. PMCID: PMC5139913

Abstract

PURPOSE: Few studies have investigated the role of race in the association of diabetes and obesity with prostate cancer aggressiveness. Here we evaluate the independent association between diabetes and obesity with prostate cancer aggressiveness in White Americans and Black Americans. METHODS: Our cross-sectional, case-only study consisted of 1,058 White Americans and 991 Black Americans from the North Carolina-Louisiana Prostate Cancer (PCaP) project. Diabetes status was determined by self-report. Obesity was determined using body mass index and calculated based on anthropometric measurements. High aggressive prostate cancer was defined as Gleason sum ≥8, or prostate-specific antigen >20 ng/ml, or Gleason sum = 7 and clinical stage cT3-cT4. The association between diabetes and obesity with high aggressive prostate cancer at diagnosis was evaluated using multivariable logistic regression and adjusted for potential confounders. RESULTS: Diabetes was not associated with high aggressive prostate cancer in the overall sample (OR 1.04; 95% CI 0.79, 1.37), White Americans (OR 1.00; 95% CI 0.65, 1.57) or Black Americans (OR 1.07; 95% CI 0.75, 1.53). Obesity, independent of diabetes, was positively associated with high aggressive prostate cancer in White Americans (OR 1.98; 95% CI 1.14, 3.43), but not in the overall sample (OR 1.37; 95% CI 0.99, 1.92) or Black Americans (OR 1.09; 95% CI 0.71, 1.67). CONCLUSIONS: Diabetes was not associated with prostate cancer aggressiveness, overall, or in either race group. Obesity, independent of diabetes, was associated with high aggressive prostate cancer only in White Americans.

URL

http://dx.doi.org/10.1007/s10552-016-0828-0

Reference Type

Journal Article

Year Published

2016

Journal Title

Cancer Causes & Control

Author(s)

Khan, Saira
Cai, Jianwen
Nielsen, Matthew E.
Troester, Melissa A.
Mohler, James L.
Fontham, Elizabeth T. H.
Hendrix, Laura H.
Farnan, Laura
Olshan, Andrew F.
Bensen, Jeannette T.

PMCID

PMC5139913

ORCiD

Olshan - 0000-0001-9115-5128