Pharmacogenetic Meta-Analysis of Genome-Wide Association Studies of LDL Cholesterol Response to Statins

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Citation

Postmus, Iris; Trompet, Stella; Deshmukh, Harshal A.; Barnes, Michael R.; Li, Xiaohui; Warren, Helen R.; Chasman, Daniel I.; Zhou, Kaixin; Arsenault, Benoit J.; & Donnelly, Louise A., et al. (2014). Pharmacogenetic Meta-Analysis of Genome-Wide Association Studies of LDL Cholesterol Response to Statins. Nature Communications, 5, 5068. PMCID: PMC4220464

Abstract

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci,

URL

http://dx.doi.org/10.1038/ncomms6068

Reference Type

Journal Article

Year Published

2014

Journal Title

Nature Communications

Author(s)

Postmus, Iris
Trompet, Stella
Deshmukh, Harshal A.
Barnes, Michael R.
Li, Xiaohui
Warren, Helen R.
Chasman, Daniel I.
Zhou, Kaixin
Arsenault, Benoit J.
Donnelly, Louise A.
Wiggins, Kerri L.
Avery, Christy L.
Griffin, Paula J.
Feng, QiPing
Taylor, Kent D.
Li, Guo
Evans, Daniel S.
Smith, Albert V.
de Keyser, Catherine E.
Johnson, Andrew D.
de Craen, Antonius J. M.
Stott, David J.
Buckley, Brendan M.
Ford, Ian
Westendorp, Rudi G. J.
Slagboom, P. Eline
Sattar, Naveed
Munroe, Patricia B.
Sever, Peter
Poulter, Neil
Stanton, Alice V.
Shields, Denis C.
O'Brien, Eoin
Shaw-Hawkins, Sue
Chen, Yii-Der Ida
Nickerson, Deborah A.
Smith, Joshua D.
Dube, Marie-Pierre
Boekholdt, S. Matthijs
Hovingh, G. Kees
Kastelein, John J. P.
McKeigue, Paul M.
Betteridge, John
Neil, Andrew
Durrington, Paul N.
Doney, Alex S. F.
Carr, Fiona
Morris, Andrew
McCarthy, Mark I.
Groop, Leif C.
Ahlqvist, Emma
Welcome Trust Case Control Consortium,
Bis, Joshua C.
Rice, Kenneth M.
Smith, Nicholas L.
Lumley, Thomas S.
Whitsel, Eric A.
Stürmer, Til
Boerwinkle, Eric A.
Ngwa, Julius S.
O'Donnell, Christopher J.
Vasan, Ramachandran S.
Wei, Wei-Qi
Wilke, Russell A.
Liu, Ching-Ti
Sun, Fangui J.
Guo, Xiuqing
Heckbert, Susan R.
Post, Wendy
Sotoodehnia, Nona
Arnold, Alice M.
Stafford, Jeanette M.
Ding, Jingzhong
Herrington, David M.
Kritchevsky, Stephen B.
Eiriksdottir, Gudny
Launer, Lenore J.
Harris, Tamara B.
Chu, Audrey Y.
Giulianini, Franco
MacFadyen, Jean G.
Barratt, Bryan J.
Nyberg, Fredrik
Stricker, Bruno H.
Uitterlinden, Andre G.
Hofman, Albert
Rivadeneira, Fernando
Emilsson, Valur
Franco, Oscar H.
Ridker, Paul M.
Gudnason, Vilmundur G.
Liu, Yongmei
Denny, Josh C.
Ballantyne, Christie M.
Rotter, Jerome I.
Cupples, L. Adrienne
Psaty, Bruce M.
Palmer, Colin N. A.
Tardif, Jean-Claude
Colhoun, Helen M.
Hitman, Graham
Krauss, Ronald M.
Jukema, J. Wouter
Caulfield, Mark J.

PMCID

PMC4220464

ORCiD

Avery - 0000-0002-1044-8162