Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans

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Citation

Smith, J. Gustav; Avery, Christy L.; Evans, Daniel S.; Nalls, Michael A.; Meng, Yan A.; Smith, Erin N.; Palmer, Cameron D.; Tanaka, Toshiko; Mehra, Reena; & Butler, Anne M., et al. (2012). Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans. Circulation: Cardiovascular Genetics, 5(6), 647-655. PMCID: PMC3568265

Abstract

BACKGROUND: Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval. METHODS AND RESULTS: First, individual estimates of African and European ancestry were inferred from genome-wide single-nucleotide polymorphism (SNP) data in 7 population-based cohorts of African Americans (n=12,097) and regressed on measured QT interval from ECGs. Second, imputation was performed for 2.8 million SNPs, and a genome-wide association study of QT interval was performed in 10 cohorts (n=13,105). There was no evidence of association between genetic ancestry and QT interval (

URL

http://dx.doi.org/10.1161/circgenetics.112.962787

Reference Type

Journal Article

Year Published

2012

Journal Title

Circulation: Cardiovascular Genetics

Author(s)

Smith, J. Gustav
Avery, Christy L.
Evans, Daniel S.
Nalls, Michael A.
Meng, Yan A.
Smith, Erin N.
Palmer, Cameron D.
Tanaka, Toshiko
Mehra, Reena
Butler, Anne M.
Young, Taylor R.
Buxbaum, Sarah G.
Kerr, Kathleen F.
Berenson, Gerald S.
Schnabel, Renate B.
Li, Guo
Ellinor, Patrick T.
Magnani, Jared W.
Chen, Wei
Bis, Joshua C.
Curb, J. David
Hsueh, Wen-Chi
Rotter, Jerome I.
Liu, Yongmei
Newman, Anne B.
Limacher, Marian C.
North, Kari E.
Reiner, Alexander P.
Quibrera, P. Miguel
Schork, Nicholas J.
Singleton, Andrew B.
Psaty, Bruce M.
Soliman, Elsayed Z.
Solomon, Allen J.
Srinivasan, Sathanur R.
Alonso, Alvaro
Wallace, Robert
Redline, Susan S.
Zhang, Zhu-Ming
Post, Wendy
Zonderman, Alan B.
Taylor, Herman A., Jr.
Murray, Sarah S.
Ferrucci, Luigi
Arking, Dan E.
Evans, Michele K.
Fox, Ervin R.
Sotoodehnia, Nona
Heckbert, Susan R.
Whitsel, Eric A.
Newton-Cheh, Christopher H.

PMCID

PMC3568265

ORCiD

Avery - 0000-0002-1044-8162