A Case-Control Analysis of Smoking and Breast Cancer in African American Women: Findings from the AMBER Consortium

Citation

Park, Song-Yi; Palmer, Julie R.; Rosenberg, Lynn A.; Haiman, Christopher A.; Bandera, Elisa V.; Bethea, Traci N.; Troester, Melissa A.; Viscidi, Emma W.; Kolonel, Laurence N.; & Olshan, Andrew F., et al. (2016). A Case-Control Analysis of Smoking and Breast Cancer in African American Women: Findings from the AMBER Consortium. Carcinogenesis, 37(6), 607-615. PMCID: PMC4876991

Abstract

Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast cancer risk by menopause and hormone receptor status [estrogen receptor-positive (ER+), ER-negative (ER-) and triple-negative (ER-, PR-, HER2-)]. The study included 5791 African American women with breast cancer and 17376 African American controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in multivariable logistic regression analysis with adjustment for study and risk factors. Results differed by menopausal status. Among postmenopausal women, positive associations were observed for long duration and greater pack-years of smoking: relative to never smoking, fully adjusted ORs were 1.14 (95% CI: 1.03-1.26) for duration >/=20 years and 1.16 (95% CI: 1.01-1.33) for >/=20 pack-years. By contrast, inverse associations were observed among premenopausal women, with ORs of 0.80 (95% CI: 0.68-95) for current smoking and 0.81 (95% CI: 0.69-0.96) for former smoking, without trends by duration. Associations among postmenopausal women were somewhat stronger for ER+ breast cancer. The findings suggest that the relation of cigarette smoking to breast cancer risk in African American women may vary by menopausal status and breast cancer subtype.

URL

http://dx.doi.org/10.1093/carcin/bgw040

Reference Type

Journal Article

Year Published

2016

Journal Title

Carcinogenesis

Author(s)

Park, Song-Yi
Palmer, Julie R.
Rosenberg, Lynn A.
Haiman, Christopher A.
Bandera, Elisa V.
Bethea, Traci N.
Troester, Melissa A.
Viscidi, Emma W.
Kolonel, Laurence N.
Olshan, Andrew F.
Ambrosone, Christine B.

PMCID

PMC4876991

ORCiD

Olshan - 0000-0001-9115-5128