Association of the Rs2242446 Polymorphism in the Norepinephrine Transporter Gene Slc6a2 and Anxious Arousal Symptoms of Posttraumatic Stress Disorder

Citation

Pietrzak, Robert H.; Sumner, Jennifer A.; Aiello, Allison E.; Uddin, Monica; Neumeister, Alexander; Guffanti, Guia; & Koenen, Karestan C. (2015). Association of the Rs2242446 Polymorphism in the Norepinephrine Transporter Gene Slc6a2 and Anxious Arousal Symptoms of Posttraumatic Stress Disorder. Journal of Clinical Psychiatry, 74(4), 537-538. PMCID: PMC4526154

Abstract

Recently, we found that greater norepinephrine transporter (NET) availability in the locus ceruleus of trauma survivors with posttraumatic stress disorder (PTSD) was associated with increased severity of anxious arousal (ie, hypervigilance and exaggerated startle) symptoms, but not any of the other empirically derived symptom clusters that characterize this disorder.1 This finding suggests that greater NET availability in the locus ceruleus may serve a compensatory function of clearing elevated synaptic norepinephrine and maintaining anxious arousal symptoms in persons with PTSD.

URL

http://dx.doi.org/10.4088/JCP.14l09346

Reference Type

Journal Article

Year Published

2015

Journal Title

Journal of Clinical Psychiatry

Author(s)

Pietrzak, Robert H.
Sumner, Jennifer A.
Aiello, Allison E.
Uddin, Monica
Neumeister, Alexander
Guffanti, Guia
Koenen, Karestan C.

PMCID

PMC4526154

ORCiD

Aiello - 0000-0001-7029-2537