Immune-Related Conditions and Acute Leukemia in Children with Down Syndrome: A Children’s Oncology Group Report

Citation

Linabery, Amy M.; Li, Wenchao; Roesler, Michelle A.; Spector, Logan G.; Gamis, Alan S.; Olshan, Andrew F.; Heerema, Nyla A.; & Ross, Julie A. (2015). Immune-Related Conditions and Acute Leukemia in Children with Down Syndrome: A Children's Oncology Group Report. Cancer Epidemiology, Biomarkers & Prevention, 24(2), 454-458. PMCID: PMC4323733

Abstract

Background: Children with Down syndrome (DS) have unique immune profiles and increased leukemia susceptibility.
Methods: Mothers of 158 children with DS diagnosed with acute leukemia at 0-19 years in 1997-2002 and 173 children with DS but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.
Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (odds ratio=9.23, 95% confidence interval: 2.33-36.59), however most instances occurred concurrent with or after the leukemia diagnosis.
Conclusions and Impact: Children with DS who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

URL

http://dx.doi.org/10.1158/1055-9965.epi-14-1181

Reference Type

Journal Article

Year Published

2015

Journal Title

Cancer Epidemiology, Biomarkers & Prevention

Author(s)

Linabery, Amy M.
Li, Wenchao
Roesler, Michelle A.
Spector, Logan G.
Gamis, Alan S.
Olshan, Andrew F.
Heerema, Nyla A.
Ross, Julie A.

PMCID

PMC4323733

ORCiD

Olshan - 0000-0001-9115-5128