Citation
Patel, Jaymin C.; Taylor, Steven M.; Juliao, Patricia C.; Parobek, Christian M.; Janko, Mark M.; Gonzalez, Luis Demetrio; Ortiz, Lucia; Padilla, Norma; Tshefu, Antoinette K.; & Emch, Michael E., et al. (2014). Genetic Evidence of Importation of Drug-Resistant Plasmodium falciparum to Guatemala from the Democratic Republic of the Congo. Emerging Infectious Diseases, 20(6), 932-940. PMCID: PMC4036788Abstract
Imported malaria threatens control and elimination efforts in countries that have low rates of transmission. In 2010, an outbreak of Plasmodium falciparum malaria was reported among United Nations peacekeeping soldiers from Guatemala who had recently returned from the Democratic Republic of the Congo (DRC). Epidemiologic evidence suggested that the soldiers were infected in the DRC, but local transmission could not be ruled out in all cases. We used population genetic analyses of neutral microsatellites to determine the outbreak source. Genetic relatedness was compared among parasites found in samples from the soldiers and parasite populations collected in the DRC and Guatemala; parasites identified in the soldiers were more closely related to those from the DRC. A phylogenetic clustering analysis confirms this identification with >99.9% confidence. Thus, results support the hypothesis that the soldiers likely imported malaria from the DRC. This study demonstrates the utility of molecular genotyping in outbreak investigations.URL
http://dx.doi.org/10.3201/eid2006.131204Reference Type
Journal ArticleYear Published
2014Journal Title
Emerging Infectious DiseasesAuthor(s)
Patel, Jaymin C.Taylor, Steven M.
Juliao, Patricia C.
Parobek, Christian M.
Janko, Mark M.
Gonzalez, Luis Demetrio
Ortiz, Lucia
Padilla, Norma
Tshefu, Antoinette K.
Emch, Michael E.
Udhayakumar, Venkatachalam
Lindblade, Kimberly A.
Meshnick, Steven R.