New Loci Associated with Birth Weight Identify Genetic Links between Intrauterine Growth and Adult Height and Metabolism

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Citation

Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O.; Sovio, Ulla; Taal, H. Rob; Hennig, Branwen J.; Bradfield, Jonathan P.; St. Pourcain, Beate; Evans, David M.; & Charoen, Pimphen, et al. (2013). New Loci Associated with Birth Weight Identify Genetic Links between Intrauterine Growth and Adult Height and Metabolism. Nature Genetics, 45(1), 76-82. PMCID: PMC3605762

Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

URL

http://dx.doi.org/10.1038/ng.2477

Reference Type

Journal Article

Year Published

2013

Journal Title

Nature Genetics

Author(s)

Horikoshi, Momoko
Yaghootkar, Hanieh
Mook-Kanamori, Dennis O.
Sovio, Ulla
Taal, H. Rob
Hennig, Branwen J.
Bradfield, Jonathan P.
St. Pourcain, Beate
Evans, David M.
Charoen, Pimphen
Kaakinen, Marika
Cousminer, Diana L.
Lehtimaki, Terho
Kreiner-Moller, Eskil
Warrington, Nicole M.
Bustamante, Mariona
Feenstra, Bjarke
Berry, Diane J.
Thiering, Elisabeth
Pfab, Thiemo
Barton, Sheila J.
Shields, Beverley M.
Kerkhof, Marjan
van Leeuwen, Elisabeth M.
Fulford, Anthony J.
Kutalik, Zoltan
Zhao, Jing Hua
den Hoed, Marcel
Mahajan, Anubha
Lindi, Virpi
Goh, Liang-Kee
Hottenga, Jouke-Jan
Wu, Ying
Raitakari, Olli T.
Harder, Marie Neergaard
Meirhaeghe, Aline
Ntalla, Ioanna
Salem, Rany M.
Jameson, Karen A.
Zhou, Kaixin
Monies, Dorota M.
Lagou, Vasiliki
Kirin, Mirna
Heikkinen, Jani
Adair, Linda S.
Alkuraya, Fowzan S.
Al-Odaib, Ali
Amouyel, Philippe
Andersson, Ehm Astrid
Bennett, Amanda J.
Blakemore, Alexandra I. F.
Buxton, Jessica L.
Dallongeville, Jean
Das, Shikta
de Geus, Eco J. C.
Estivill, Xavier
Flexeder, Claudia
Froguel, Philippe
Geller, Frank
Godfrey, Keith M.
Gottrand, Frederic
Groves, Christopher J.
Hansen, Torben
Hirschhorn, Joel N.
Hofman, Albert
Hollegaard, Mads V.
Hougaard, David M.
Hypponen, Elina
Inskip, Hazel M.
Isaacs, Aaron J.
Jorgensen, Torben
Kanaka-Gantenbein, Christina
Kemp, John P.
Kiess, Wieland
Kilpelainen, Tuomas O.
Klopp, Norman
Knight, Bridget A.
Kuzawa, Christopher W.
McMahon, George
Newnham, John P.
Niinikoski, Harri
Oostra, Ben A.
Pedersen, Louise
Postma, Dirkje S.
Ring, Susan M.
Rivadeneira, Fernando
Robertson, Neil R.
Sebert, Sylvain
Simell, Olli
Slowinski, Torsten
Tiesler, Carla M. T.
Tonjes, Anke
Vaag, Allan A.
Viikari, Jorma S.
Vink, Jacqueline M.
Vissing, Nadja Hawwa
Wareham, Nicholas J.
Willemsen, Gonneke
Witte, Daniel R.
Zhang, Haitao
Zhao, Jianhua

PMCID

PMC3605762

ORCiD

Adair - 0000-0002-3670-8073