Morbidity and Mortality Profile of Human Immunodeficiency Virus-Infected Patients with and without Hepatitis C Co-Infection

Citation

Mayor, Angel M.; Gomez, Maria A.; Fernandez, Diana M.; Rios-Olivares, Eddy; Thomas, James C.; & Hunter, Robert F. (2006). Morbidity and Mortality Profile of Human Immunodeficiency Virus-Infected Patients with and without Hepatitis C Co-Infection. American Journal of Tropical Medicine and Hygiene, 74(2), 239-245. PMCID: PMC3938120

Abstract

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is an important and frequent scenario, predominantly in injecting drug users (IDUs). The present study evaluated morbidity and mortality variation in HIV-infected patients with and without HCV co-infection. Co-infection prevalence was determined in 356 HIV-infected persons. Their clinical manifestations, laboratory findings, risk factors, HIV therapies, and mortality rates were evaluated. The prevalence of HCV was 54% in the overall group and 81% in IDUs, with a predominance of HCV genotype 1. Mortality rates were similar in patients with and without co-infection; however, co-infected patients had significantly higher liver damage as a cause of mortality when compared with those who were not co-infected. The high prevalence of HCV and an emerging mortality from liver diseases showed the significance of this co-infection in the HIV epidemic. Primary and secondary prevention are necessary to reduce the expanding impact of HCV infection in HIV patients.

URL

http://www.ajtmh.org/docserver/fulltext/14761645/74/2/0740239.pdf?expires=1588277957&id=id&accname=guest&checksum=03A813CA4EA4085C9A3B773E93FED652

Reference Type

Journal Article

Year Published

2006

Journal Title

American Journal of Tropical Medicine and Hygiene

Author(s)

Mayor, Angel M.
Gomez, Maria A.
Fernandez, Diana M.
Rios-Olivares, Eddy
Thomas, James C.
Hunter, Robert F.

PMCID

PMC3938120

ORCiD

Thomas, JC - 0000-0002-2225-2052