Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

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Citation

Hashibe, Mia; Brennan, Paul; Chuang, Shu-Chun; Boccia, Stefania; Castellsague, Xavier; Chen, Chu; Curado, Maria Paula; Dal Maso, Luigino; Daudt, Alexander W.; & Fabianova, Eleonora, et al. (2009). Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiology, Biomarkers & Prevention, 18(2), 541-550. PMCID: PMC3051410

Abstract

Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden.
Methods: We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (?) and population attributable risks (PAR).
Results: A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (? = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to tobacco alone, and 35% was due to tobacco and alcohol combined. The total PAR differed by subsite (64% for oral cavity cancer, 72% for pharyngeal cancer, 89% for laryngeal cancer), by sex (74% for men, 57% for women), by age (33% for cases <45 years, 73% for cases >60 years), and by region (84% in Europe, 51% in North America, 83% in Latin America).
Conclusions: Our results confirm that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk. However, a substantial proportion of head and neck cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head and neck cancer among women and among young-onset cases.

URL

http://dx.doi.org/10.1158/1055-9965.EPI-08-0347

Reference Type

Journal Article

Year Published

2009

Journal Title

Cancer Epidemiology, Biomarkers & Prevention

Author(s)

Hashibe, Mia
Brennan, Paul
Chuang, Shu-Chun
Boccia, Stefania
Castellsague, Xavier
Chen, Chu
Curado, Maria Paula
Dal Maso, Luigino
Daudt, Alexander W.
Fabianova, Eleonora
Fernandez, Leticia
Wunsch-Filho, Victor
Franceschi, Silvia
Hayes, Richard B.
Herrero, Rolando
Kelsey, Karl T.
Koifman, Sergio
La Vecchia, Carlo
Lazarus, Philip
Levi, Fabio
Lence, Juan J.
Mates, Dana
Matos, Elena L.
Menezes, Ana M.
McClean, Michael D.
Muscat, Joshua E.
Eluf-Neto, Jose
Olshan, Andrew F.
Purdue, Mark P.
Rudnai, Peter
Schwartz, Stephen M.
Smith, Elaine
Sturgis, Erich M.
Szeszenia-Dabrowska, Neonila
Talamini, Renato
Wei, Qingyi
Winn, Deborah M.
Shangina, Oxana
Pilarska, Agnieszka
Zhang, Zuo-Feng
Ferro, Gilles
Berthiller, Julien
Boffetta, Paolo

PMCID

PMC3051410

ORCiD

Olshan - 0000-0001-9115-5128