Citation
Lubin, Jay H.; Gaudet, Mia M.; Olshan, Andrew F.; Kelsey, Karl T.; Boffetta, Paolo; Brennan, Paul; Castellsague, Xavier; Chen, Chu; Curado, Maria Paula; & Dal Maso, Luigino, et al. (2010). Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-Control Data. American Journal of Epidemiology, 171(12), 1250-1261. PMCID: PMC2915496Abstract
Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.URL
http://dx.doi.org/10.1093/aje/kwq088Reference Type
Journal ArticleYear Published
2010Journal Title
American Journal of EpidemiologyAuthor(s)
Lubin, Jay H.Gaudet, Mia M.
Olshan, Andrew F.
Kelsey, Karl T.
Boffetta, Paolo
Brennan, Paul
Castellsague, Xavier
Chen, Chu
Curado, Maria Paula
Dal Maso, Luigino
Daudt, Alexander W.
Fabianova, Eleonora
Fernandez, Leticia
Wunsch-Filho, Victor
Franceschi, Silvia
Herrero, Rolando
Koifman, Sergio
La Vecchia, Carlo
Lazarus, Philip
Levi, Fabio
Lissowska, Jolanta
Mates, Ioan Nicolae
Matos, Elena L.
McClean, Michael D.
Menezes, Ana M.
Morgenstern, Hal
Muscat, Joshua E.
Eluf-Neto, Jose
Purdue, Mark P.
Rudnai, Peter
Schwartz, Stephen M.
Shangina, Oxana
Sturgis, Erich M.
Szeszenia-Dabrowska, Neonila
Talamini, Renato
Wei, Qingyi
Winn, Deborah M.
Zhang, Zuo-Feng
Hashibe, Mia
Hayes, Richard B.