Cessation of Alcohol Drinking, Tobacco Smoking and the Reversal of Head and Neck Cancer Risk

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Citation

Marron, Manuela; Boffetta, Paolo; Zhang, Zuo-Feng; Zaridze, David; Wünsch-Filho, Victor; Winn, Deborah M.; Wei, Qingyi; Talamini, Renato; Szeszenia-Dabrowska, Neonila; & Sturgis, Erich M., et al. (2010). Cessation of Alcohol Drinking, Tobacco Smoking and the Reversal of Head and Neck Cancer Risk. International Journal of Epidemiology, 39(1), 182-196. PMCID: PMC2817090

Abstract

BACKGROUND: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers.
METHODS: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models.
RESULTS: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after >/=20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after >/=20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers.
CONCLUSIONS: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

URL

http://dx.doi.org/10.1093/ije/dyp291

Reference Type

Journal Article

Year Published

2010

Journal Title

International Journal of Epidemiology

Author(s)

Marron, Manuela
Boffetta, Paolo
Zhang, Zuo-Feng
Zaridze, David
Wünsch-Filho, Victor
Winn, Deborah M.
Wei, Qingyi
Talamini, Renato
Szeszenia-Dabrowska, Neonila
Sturgis, Erich M.
Smith, Elaine
Schwartz, Stephen M.
Rudnai, Peter
Purdue, Mark P.
Olshan, Andrew F.
Eluf-Neto, Jose
Muscat, Joshua E.
Morgenstern, Hal
Menezes, Ana M.
McClean, Michael D.
Matos, Elena L.
Mates, Ioan Nicolae
Lissowska, Jolanta
Levi, Fabio
Lazarus, Philip
La Vecchia, Carlo
Koifman, Sergio
Kelsey, Karl T.
Herrero, Rolando
Hayes, Richard B.
Franceschi, Silvia
Fernandez, Leticia
Fabianova, Eleonora
Daudt, Alexander W.
Dal Maso, Luigino
Curado, Maria Paula
Cadoni, Gabriella
Chen, Chu
Castellsague, Xavier
Boccia, Stefania
Benhamou, Simone
Ferro, Gilles
Berthiller, Julien
Brennan, Paul
Moller, Henrik
Hashibe, Mia

PMCID

PMC2817090

ORCiD

Olshan - 0000-0001-9115-5128