Estimation of the Relative Excess Risk Due to Interaction and Associated Confidence Bounds

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Citation

Richardson, David B. & Kaufman, Jay S. (2009). Estimation of the Relative Excess Risk Due to Interaction and Associated Confidence Bounds. American Journal of Epidemiology, 169(6), 756-760. PMCID: PMC3139969

Abstract

The relative excess risk due to interaction (RERI) provides a useful metric of departure from additivity of effects on a relative risk scale. In this paper, the authors show that RERI is identical to the product term in a linear odds ratio or a linear relative risk model. SAS and STATA codes are provided for fitting a linear odds ratio model that directly parameterizes RERI. In addition, this paper presents a method for obtaining likelihood-based 95% confidence bound estimates for RERI. The authors show that likelihood-based confidence intervals may differ substantially from the asymptotic confidence interval estimates advocated by previous authors. The approach presented in this paper should facilitate estimation of RERI and associated likelihood-based confidence bounds, by using standard statistical packages.

URL

http://dx.doi.org/10.1093/aje/kwn411

Reference Type

Journal Article

Year Published

2009

Journal Title

American Journal of Epidemiology

Author(s)

Richardson, David B.
Kaufman, Jay S.

PMCID

PMC3139969