Type of Alcoholic Beverage and Risk of Head and Neck Cancer–A Pooled Analysis within the INHANCE Consortium

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Citation

Purdue, Mark P.; Hashibe, Mia; Berthiller, Julien; La Vecchia, Carlo; Dal Maso, Luigino; Herrero, Rolando; Franceschi, Silvia; Castellsague, Xavier; Wei, Qingyi; & Sturgis, Erich M., et al. (2009). Type of Alcoholic Beverage and Risk of Head and Neck Cancer--A Pooled Analysis within the INHANCE Consortium. American Journal of Epidemiology, 169(2), 132-142. PMCID: PMC2727255

Abstract

The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption of beer, wine, and liquor. In particular, they calculated associations with different measures of beverage consumption separately for subjects who drank beer only (858 cases, 986 controls), for liquor-only drinkers (499 cases, 527 controls), and for wine-only drinkers (1,021 cases, 2,460 controls), with alcohol never drinkers (1,124 cases, 3,487 controls) used as a common reference group. The authors observed similar associations with ethanol-standardized consumption frequency for beer-only drinkers (odds ratios (ORs) = 1.6, 1.9, 2.2, and 5.4 for 30 drinks per week, respectively; P(trend) < 0.0001) and liquor-only drinkers (ORs = 1.6, 1.5, 2.3, and 3.6; P < 0.0001). Among wine-only drinkers, the odds ratios for moderate levels of consumption frequency approached the null, whereas those for higher consumption levels were comparable to those of drinkers of other beverage types (ORs = 1.1, 1.2, 1.9, and 6.3; P < 0.0001). Study findings suggest that the relative risks of head and neck cancer for beer and liquor are comparable. The authors observed weaker associations with moderate wine consumption, although they cannot rule out confounding from diet and other lifestyle factors as an explanation for this finding. Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution.

URL

http://dx.doi.org/10.1093/aje/kwn306

Reference Type

Journal Article

Year Published

2009

Journal Title

American Journal of Epidemiology

Author(s)

Purdue, Mark P.
Hashibe, Mia
Berthiller, Julien
La Vecchia, Carlo
Dal Maso, Luigino
Herrero, Rolando
Franceschi, Silvia
Castellsague, Xavier
Wei, Qingyi
Sturgis, Erich M.
Morgenstern, Hal
Zhang, Zuo-Feng
Levi, Fabio
Talamini, Renato
Smith, Elaine
Muscat, Joshua E.
Lazarus, Philip
Schwartz, Stephen M.
Chen, Chu
Eluf-Neto, Jose
Wünsch-Filho, Victor
Zaridze, David
Koifman, Sergio
Curado, Maria Paula
Benhamou, Simone
Matos, Elena L.
Szeszenia-Dabrowska, Neonila
Olshan, Andrew F.
Lence, Juan J.
Menezes, Ana M.
Daudt, Alexander W.
Mates, Ioan Nicolae
Pilarska, Agnieszka
Fabianova, Eleonora
Rudnai, Peter
Winn, Deborah M.
Ferro, Gilles
Brennan, Paul
Boffetta, Paolo
Hayes, Richard B.

PMCID

PMC2727255

ORCiD

Olshan - 0000-0001-9115-5128