Salivary Progesterone and Estriol among Pregnant Women Treated with 17-Alpha-Hydroxyprogesterone Caproate or Placebo

Citation

Klebanoff, Mark A.; Meis, Paul J.; Dombrowski, Mitchell P.; Zhao, Yuan; Moawad, Atef H.; Northen, Allison; Sibai, Baha M.; Iams, Jay D.; Varner, Michael W.; & Caritis, Steve N., et al. (2008). Salivary Progesterone and Estriol among Pregnant Women Treated with 17-Alpha-Hydroxyprogesterone Caproate or Placebo. American Journal of Obstetrics & Gynecology, 199(5), 506.e1-7. PMCID: PMC2794481

Abstract

Objective: The objectives of the study was to determine whether salivary progesterone (P) or estriol (E3) concentration at 16-20 weeks' gestation predicts preterm birth or the response to 17?-hydroxyprogesterone caproate (17OHPC) and whether 17OHPC treatment affected the trajectory of salivary P and E3 as pregnancy progressed.
Study Design: This was a secondary analysis of a clinical trial of 17OHPC to prevent preterm birth. Baseline saliva was assayed for P and E3. Weekly salivary samples were obtained from 40 women who received 17OHPC and 40 who received placebo in a multicenter randomized trial of 17OHPC to prevent recurrent preterm delivery.
Results: Both low and high baseline saliva P and E3 were associated with a slightly increased risk of preterm birth. However, 17OHPC prevented preterm birth comparably, regardless of baseline salivary hormone concentrations. 17OHPC did not alter the trajectory of salivary P over pregnancy, but it significantly blunted the rise in salivary E3 as well as the rise in the E3/P ratio.
Conclusion: 17OHPC flattened the trajectory of E3 in the second half of pregnancy, suggesting that the drug influences the fetoplacental unit.

URL

http://dx.doi.org/10.1016/j.ajog.2008.03.003

Reference Type

Journal Article

Year Published

2008

Journal Title

American Journal of Obstetrics & Gynecology

Author(s)

Klebanoff, Mark A.
Meis, Paul J.
Dombrowski, Mitchell P.
Zhao, Yuan
Moawad, Atef H.
Northen, Allison
Sibai, Baha M.
Iams, Jay D.
Varner, Michael W.
Caritis, Steve N.
O'Sullivan, Mary Jo
Leveno, Kenneth J.
Miodovnik, Menachem
Conway, Deborah
Wapner, Ronald J.
Carpenter, Marshall W.
Mercer, Brian M.
Ramin, Susan M.
Thorp, John M., Jr.
Peaceman, Alan M., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network

PMCID

PMC2794481

ORCiD

Thorp - 0000-0002-9307-6690