Citation
Siega-Riz, Anna Maria; Savitz, David A; .; Zeisel, Steven H.; Thorp, John M., Jr.; & Herring, Amy H. (2004). Second Trimester Folate Status and Preterm Birth. American Journal of Obstetrics & Gynecology, 191(6), 1851-1857.Abstract
OBJECTIVE: The purpose of this study was to show that maternal folate status during pregnancy may be related to preterm birth.STUDY DESIGN: Women were recruited at 24 to 29 weeks' gestation from 1995 to 2000 into the Pregnancy, Infection, and Nutrition Study. Those who completed an interview and a food frequency questionnaire, or provided a blood sample for radioassay of serum (n = 2026) and red blood cell (n = 1034) folate were included.
RESULTS: Mean daily dietary folate intake was 463 microg (SD +/- 248). Intake =500 microg was associated with increased preterm delivery (RR = 1.8, 95% CI 1.4-2.6) controlling for total energy intake. Serum folate levels <16.3 ng/mL and red blood cell folate levels =626.6 ng/mL yielded adjusted risk ratios of 1.8 (95% CI 1.3-2.5) and 1.7 (95% CI 1.1-2.6), respectively. Patterns were similar for spontaneous and overall preterm birth.
CONCLUSION: These results support the hypothesis that low folate levels during the second trimester of pregnancy are associated with an increased risk of preterm birth.
URL
http://dx.doi.org/10.1016/j.ajog.2004.07.076Reference Type
Journal ArticleYear Published
2004Journal Title
American Journal of Obstetrics & GynecologyAuthor(s)
Siega-Riz, Anna MariaSavitz, David A
.
Zeisel, Steven H.
Thorp, John M., Jr.
Herring, Amy H.
ORCiD
Siega-Riz - 0000-0002-1303-4248Thorp - 0000-0002-9307-6690