Citation
Knee, Jackie; Sumner, Trent; Adriano, Zaida; Anderson, Claire; Bush, Farran; Capone, Drew; Casmo, Veronica; Holcomb, David A.; Kolsky, Pete; & MacDougall, Amy, et al. (2021). Effects of an Urban Sanitation Intervention on Childhood Enteric Infection and Diarrhea in Maputo, Mozambique: A Controlled Before-and-After Trial. Elife, 10, e62278. PMCID: PMC8121544Abstract
We conducted a controlled before-and-after trial to evaluate the impact of an onsite urban sanitation intervention on the prevalence of enteric infection, soil transmitted helminth re-infection, and diarrhea among children in Maputo, Mozambique. A non-governmental organization replaced existing poor-quality latrines with pour-flush toilets with septic tanks serving household clusters. We enrolled children aged 1-48 months at baseline and measured outcomes before and 12 and 24 months after the intervention, with concurrent measurement among children in a comparable control arm. Despite nearly exclusive use, we found no evidence that intervention affected the prevalence of any measured outcome after 12 or 24 months of exposure. Among children born into study sites after intervention, we observed a reduced prevalence of Trichuris and Shigella infection relative to the same age group at baseline (<2 years old). Protection from birth may be important to reduce exposure to and infection with enteric pathogens in this setting.URL
http://dx.doi.org/10.7554/eLife.62278Reference Type
Journal ArticleYear Published
2021Journal Title
ElifeAuthor(s)
Knee, JackieSumner, Trent
Adriano, Zaida
Anderson, Claire
Bush, Farran
Capone, Drew
Casmo, Veronica
Holcomb, David A.
Kolsky, Pete
MacDougall, Amy
Molotkova, Evgeniya
Braga, Judite Monteiro
Russo, Celina
Schmidt, Wolf P.
Stewart, Jill
Zambrana, Winnie
Zuin, Valentina
Nalá, Rassul
Cumming, Oliver
Brown, Joe