Estimating the Proportion of Clinically Suspected Cholera Cases that are True Vibrio Cholerae Infections: A Systematic Review and Meta-Analysis

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Citation

Wiens, Kirsten E.; Xu, Hanmeng; Zou, Kaiyue; Mwaba, John; Lessler, Justin; Malembaka, Espoir B.; Demby, Maya N.; Bwire, Godfrey; Qadri, Firdausi; & Lee, Elizabeth C., et al. (2023). Estimating the Proportion of Clinically Suspected Cholera Cases that are True Vibrio Cholerae Infections: A Systematic Review and Meta-Analysis. PLOS Medicine, 20(9), e1004286. PMCID: PMC10538743

Abstract

BACKGROUND: Cholera surveillance relies on clinical diagnosis of acute watery diarrhea. Suspected cholera case definitions have high sensitivity but low specificity, challenging our ability to characterize cholera burden and epidemiology. Our objective was to estimate the proportion of clinically suspected cholera that are true Vibrio cholerae infections and identify factors that explain variation in positivity.
METHODS AND FINDINGS: We conducted a systematic review of studies that tested

URL

http://dx.doi.org10.1371/journal.pmed.1004286

Reference Type

Journal Article

Year Published

2023

Journal Title

PLOS Medicine

Author(s)

Wiens, Kirsten E.
Xu, Hanmeng
Zou, Kaiyue
Mwaba, John
Lessler, Justin
Malembaka, Espoir B.
Demby, Maya N.
Bwire, Godfrey
Qadri, Firdausi
Lee, Elizabeth C.
Azman, Andrew S.

Article Type

Review

PMCID

PMC10538743

ORCiD

Lessler - 0000-0002-9741-8109