Influence of Alcohol Consumption and Alcohol Metabolism Variants on Breast Cancer Risk among Black Women: Results from the Amber Consortium

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Citation

Young, Kristin L.; Olshan, Andrew F.; Lunetta, Kathryn; Graff, Mariaelisa; Williams, Lindsay A.; Yao, Song; Zirpoli, Gary R.; Troester, Melissa A.; & Palmer, Julie R. (2023). Influence of Alcohol Consumption and Alcohol Metabolism Variants on Breast Cancer Risk among Black Women: Results from the Amber Consortium. Breast Cancer Research, 25(1), 66. PMCID: PMC10259046

Abstract

BACKGROUND: Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among women of African ancestry.
METHODS: Our analysis from the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium included 2889 U.S. Black women who were current drinkers at the time of breast cancer diagnosis (N cases = 715) and had available genetic data for four ethanol metabolism genomic regions (ADH, ALDH, CYP2E1, and ALDH2). We used generalized estimating equations to calculate genetic effects, gene* alcohol consumption (

URL

http://dx.doi.org/10.1186/s13058-023-01660-1

Reference Type

Journal Article

Year Published

2023

Journal Title

Breast Cancer Research

Author(s)

Young, Kristin L.
Olshan, Andrew F.
Lunetta, Kathryn
Graff, Mariaelisa
Williams, Lindsay A.
Yao, Song
Zirpoli, Gary R.
Troester, Melissa A.
Palmer, Julie R.

Article Type

Regular

PMCID

PMC10259046

Data Set/Study

African American Breast Cancer Epidemiology and Risk (AMBER) Consortium

Continent/Country

United States

State

Nonspecific

Race/Ethnicity

Black

ORCiD

Olshan - 0000-0001-9115-5128