Citation
Afghahi, Anosheh; Purington, Natasha; Han, Summer S.; Desai, Manisha; Pierson, Emma; Mathur, Maya B.; Seto, Tina; Thompson, Caroline A.; Rigdon, Joseph; & Telli, Melinda L., et al. (2018). Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer. Clinical Cancer Research, 24(12), 2851-2858. PMCID: PMC6366842Abstract
Purpose: Tumor-infiltrating lymphocytes (TIL) in pretreatment biopsies are associated with improved survival in triple-negative breast cancer (TNBC). We investigated whether higher peripheral lymphocyte counts are associated with lower breast cancer-specific mortality (BCM) and overall mortality (OM) in TNBC.Experimental Design: Data on treatments and diagnostic tests from electronic medical records of two health care systems were linked with demographic, clinical, pathologic, and mortality data from the California Cancer Registry. Multivariable regression models adjusted for age, race/ethnicity, socioeconomic status, cancer stage, grade, neoadjuvant/adjuvant chemotherapy use, radiotherapy use, and germline BRCA1/2 mutations were used to evaluate associations between absolute lymphocyte count (ALC), BCM, and OM. For a subgroup with TIL data available, we explored the relationship between TILs and peripheral lymphocyte counts.
Results: A total of 1,463 stage I-III TNBC patients were diagnosed from 2000 to 2014; 1,113 (76%) received neoadjuvant/adjuvant chemotherapy within 1 year of diagnosis. Of 759 patients with available ALC data, 481 (63.4%) were ever lymphopenic (minimum ALC <1.0 K/
URL
http://dx.doi.org/10.1158/1078-0432.CCR-17-1323Reference Type
Journal ArticleYear Published
2018Journal Title
Clinical Cancer ResearchAuthor(s)
Afghahi, AnoshehPurington, Natasha
Han, Summer S.
Desai, Manisha
Pierson, Emma
Mathur, Maya B.
Seto, Tina
Thompson, Caroline A.
Rigdon, Joseph
Telli, Melinda L.
Badve, Sunil S.
Curtis, Christina N.
West, Robert B.
Horst, Kathleen
Gomez, Scarlett L.
Ford, James M.
Sledge, George W.
Kurian, Allison W.