Citation
Gaber, Charles E.; Shaheen, Nicholas J.; Sandler, Robert S.; Edwards, Jessie K.; Nichols, Hazel B.; Sanoff, Hanna K.; & Lund, Jennifer L. (2022). Patterns of Care amongst Older Adults Diagnosed with Locally Advanced Esophageal Cancer: A Cohort Study. Journal of Geriatric Oncology, 13(8), 1178-1187.Abstract
INTRODUCTION: Since the early 2010s, neoadjuvant chemoradiation followed by esophagectomy (trimodal therapy) has been a recommended treatment for patients diagnosed with locally advanced esophageal cancer. However, it may also add treatment-related toxicity, particularly for older adults with significant comorbidity and frailty burdens. We examined contemporary patterns of care in older adults, which have not been well characterized.MATERIALS AND METHODS: We used the Surveillance Epidemiology and End Results-Medicare database to identify a cohort of US adults aged 66 years and older diagnosed with incident locally advanced esophageal cancer between 2004 and 2017. Calendar year age-standardized percentages of treatment receipt were calculated. Joinpoint regression was used to detect temporal trends in treatment receipt. Descriptive associations between patient factors and treatment were assessed. Trend analyses quantified how the percentage of trimodal and definitive chemoradiation (no surgery) patients receiving cisplatin-based, carboplatin-based, and other chemotherapy regimens evolved over time.
RESULTS: In total, 4332 adults aged
URL
http://dx.doi.org/10.1016/j.jgo.2022.08.009Reference Type
Journal ArticleYear Published
2022Journal Title
Journal of Geriatric OncologyAuthor(s)
Gaber, Charles E.Shaheen, Nicholas J.
Sandler, Robert S.
Edwards, Jessie K.
Nichols, Hazel B.
Sanoff, Hanna K.
Lund, Jennifer L.