Citation
Harris, Benjamin S.; Steiner, Anne Z.; Faurot, Keturah R.; Long, Anneliese; & Jukic, Anne Marie Z. (2023). Systemic Inflammation and Menstrual Cycle Length in a Prospective Cohort Study. American Journal of Obstetrics & Gynecology, 228(2), 215.e1-17. PMCID: PMC9877159Abstract
BACKGROUND: Local inflammation plays an important role in normal folliculogenesis and ovulation, and conditions of chronic systemic inflammation, such as obesity and PCOS, can disrupt normal follicular dynamics.OBJECTIVE: To determine the association between systemic inflammation, as measured by C-Reactive Protein (CRP) levels, and menstrual cycle length.
STUDY DESIGN: Secondary analysis using data from Time to Conceive (TTC), a prospective time-to-pregnancy cohort study. The association between cycle length and CRP was analyzed using multivariable linear mixed and marginal models adjusted for age, race, education, body mass index, time since oral contraceptive use, alcohol, smoking, caffeine consumption, and exercise. TTC enrolled women aged 30 to 44 with no history of infertility who were attempting to conceive for <3 months. Serum C-Reactive Protein (CRP) levels were measured on cycle day 2, 3, or 4. Participants recorded daily menstrual cycle data for
URL
http://dx.doi.org/10.1016/j.ajog.2022.10.008Reference Type
Journal ArticleYear Published
2023Journal Title
American Journal of Obstetrics & GynecologyAuthor(s)
Harris, Benjamin S.Steiner, Anne Z.
Faurot, Keturah R.
Long, Anneliese
Jukic, Anne Marie Z.