Citation
Davidson, Trent; Braudt, David B.; Keers, Robert; Assary, Elham; Harris, Kathleen Mullan; & Boardman, Jason D. (2021). Genome-Wide Stress Sensitivity Moderates the Stress-Depression Relationship in a Nationally Representative Sample of Adults. Scientific Reports, 11(1), 20332. PMCID: PMC8514581Abstract
We re-evaluate the findings of one of the most cited and disputed papers in gene-environment interaction (GxE) literature. In 2003, a paper was published in Science in which the authors demonstrated that the relationship between stress and depression is moderated by a polymorphism in the promoter region (5-HTTLPR) of the gene SLC6A4. Replication has been weak and led many to challenge the overall significance of GxE research. Here, we utilize data from Add Health, a large, nationally representative, and well-powered longitudinal study to re-examine the genetic determinants of stress sensitivity. We characterize environmental sensitivity using a genome-wide polygenic indicator rather than relying on one polymorphism in a single candidate gene. Our results provide support for the stress-diathesis perspective and validate the scientific contributions of the original paper.URL
http://dx.doi.org/10.1038/s41598-021-98684-4Reference Type
Journal ArticleYear Published
2021Journal Title
Scientific ReportsAuthor(s)
Davidson, TrentBraudt, David B.
Keers, Robert
Assary, Elham
Harris, Kathleen Mullan
Boardman, Jason D.