Epigenetic Predictors of All-Cause Mortality Are Associated with Objective Measures of Neighborhood Disadvantage in an Urban Population

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Citation

Ward-Caviness, Cavin K.; Pu, Shirley; Martin, Chantel L.; Galea, Sandro; Uddin, Monica; Wildman, Derek E.; Koenen, Karestan C.; & Aiello, Allison E. (2020). Epigenetic Predictors of All-Cause Mortality Are Associated with Objective Measures of Neighborhood Disadvantage in an Urban Population. Clinical Epigenetics, 12(1), 44. PMCID: PMC7065313

Abstract

BACKGROUND: Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation of the role that molecular indicators may play in mediating neighborhood exposures, there has been little effort to incorporate newly developed epigenetic biomarkers into our understanding of neighborhood characteristics and health outcomes.
METHODS: Using 157 participants of the Detroit Neighborhood Health Study with detailed assessments of neighborhood characteristics and genome-wide DNA methylation profiling via the Illumina 450K methylation array, we assessed the relationship between objective neighborhood characteristics and a validated DNA methylation-based epigenetic mortality risk score (eMRS). Associations were adjusted for age, race, sex, ever smoking, ever alcohol usage, education, years spent in neighborhood, and employment. A secondary model additionally adjusted for personal neighborhood perception. We summarized 19 neighborhood quality indicators assessed for participants into 9 principal components which explained over 90% of the variance in the data and served as metrics of objective neighborhood quality exposures.
RESULTS: Of the nine principal components utilized for this study, one was strongly associated with the eMRS (

URL

http://dx.doi.org/10.1186/s13148-020-00830-8

Reference Type

Journal Article

Year Published

2020

Journal Title

Clinical Epigenetics

Author(s)

Ward-Caviness, Cavin K.
Pu, Shirley
Martin, Chantel L.
Galea, Sandro
Uddin, Monica
Wildman, Derek E.
Koenen, Karestan C.
Aiello, Allison E.

Article Type

Regular

PMCID

PMC7065313

Data Set/Study

Detroit Neighborhood Health Study (DNHS)

Continent/Country

United States of America

State

Michigan

ORCiD

Aiello - 0000-0001-7029-2537
Martin, C. - 0000-0003-1907-0810