Citation
Noppert, Grace A.; Feinstein, Lydia; Dowd, Jennifer Beam; Stebbins, Rebecca C.; Zang, Emma; Needham, Belinda L.; Meier, Helen C. S.; Simanek, Amanda M.; & Aiello, Allison E. (2020). Pathogen Burden and Leukocyte Telomere Length in the United States. Immunity & Ageing, 17(1), 36. PMCID: PMC7677839Abstract
Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimated cross-sectional associations between seropositivity to five persistent pathogens (Herpes Simplex Virus Type-1 (HSV-1), Herpes Simplex Virus Type-2 (HSV-2), cytomegalovirus (CMV), Helicobacter pylori (H.pylori), and Hepatitis B) as well as total pathogen burden and leukocyte telomere length. Data were derived from the National Health and Nutrition Examination Survey (1999–2000) for individuals 20–49 years of age, N = 1708. We analyzed the influence of each pathogen separately, a pathogen count score and a latent class model of pathogen burden on log telomere length using linear regression models, adjusted for covariates.URL
https://doi.org/10.1186/s12979-020-00206-9Reference Type
Journal ArticleYear Published
2020Journal Title
Immunity & AgeingAuthor(s)
Noppert, Grace A.Feinstein, Lydia
Dowd, Jennifer Beam
Stebbins, Rebecca C.
Zang, Emma
Needham, Belinda L.
Meier, Helen C. S.
Simanek, Amanda M.
Aiello, Allison E.
Article Type
RegularPMCID
PMC7677839Data Set/Study
National Health and Nutrition Examination Survey (NHANES)Continent/Country
United States of AmericaState
NonspecificORCiD
Aiello - 0000-0001-7029-2537Noppert - 0000-0002-2040-960x