Citation
Noppert, Grace A.; Aiello, Allison E.; O'Rand, Angela M.; & Cohen, Harvey Jay (2020). Race/Ethnic and Educational Disparities in the Association between Pathogen Burden and a Laboratory-Based Cumulative Deficits Index. Journal of Racial and Ethnic Health Disparities, 7(1), 99-108. PMCID: PMC6980710Abstract
BACKGROUND: Disparities in adult morbidity and mortality may be rooted in patterns of biological dysfunction in early life. We sought to examine the association between pathogen burden and a cumulative deficits index (CDI), conceptualized as a pre-clinical marker of an unhealthy biomarker profile, specifically focusing on patterns across levels of social disadvantage.METHODS: Using the data from the National Health and Nutrition Examination Survey 2003-2004 wave (aged 20-49 years), we examined the association of pathogen burden, composed of seven pathogens, with the CDI. The CDI comprised 28 biomarkers corresponding to available clinical laboratory measures. Models were stratified by race/ethnicity and education level.
RESULTS: The CDI ranged from 0.04 to 0.78. Nearly half of Blacks were classified in the high burden pathogen class compared with 8% of Whites. Among both Mexican Americans and other Hispanic groups, the largest proportion of individuals were classified in the common pathogens class. Among educational classes, 19% of those with less than a high school education were classified in the high burden class compared with 7% of those with at least a college education. Blacks in the high burden pathogen class had a CDI 0.05 greater than those in the low burden class (P < 0.05). Whites in the high burden class had a CDI only 0.03 greater than those in the low burden class (P < 0.01).
DISCUSSION: Our findings suggest there are significant social disparities in the distribution of pathogen burden across race/ethnic groups, and the effects of pathogen burden may be more significant for socially disadvantaged individuals.
URL
http://dx.doi.org/10.1007/s40615-019-00638-0Reference Type
Journal ArticleYear Published
2020Journal Title
Journal of Racial and Ethnic Health DisparitiesAuthor(s)
Noppert, Grace A.Aiello, Allison E.
O'Rand, Angela M.
Cohen, Harvey Jay
Article Type
RegularPMCID
PMC6980710Data Set/Study
National Health and Nutrition Examination Survey (NHANES)Continent/Country
United States of AmericaState
NonspecificRace/Ethnicity
BlackWhite
Mexican American
Hispanic/Latinx
ORCiD
Aiello - 0000-0001-7029-2537Noppert - 0000-0002-2040-960x