Citation
Martin, Chantel L.; Vladutiu, Catherine J.; Zikry, Tarek M.; Grace, Matthew R.; & Siega-Riz, Anna Maria (2019). Maternal Lipid Levels during Pregnancy and Child Weight Status at 3 Years of Age. Pediatric Obesity, 14(4), e12485. PMCID: PMC6545288Abstract
BACKGROUND: The intrauterine environment is critical in the development of child obesity.OBJECTIVE: To investigate the association between maternal lipid levels during pregnancy and child weight status.
METHODS: Maternal lipid levels (total cholesterol, high-density and low-density lipoprotein cholesterol, triglycerides) collected from fasting blood samples collected at less than 20 and 24-29 weeks' gestation and child weight status at age 3 were examined prospectively among 183 mother-child dyads enrolled in the Pregnancy, Infection, and Nutrition. Measured height and weight at 3 years were used to calculate age- and sex-specific body mass index z-scores. Child risk of overweight/obesity was defined as body mass index greater than or equal to 85th percentile for age and sex. Regression models estimated the association between maternal lipid levels and child body mass index z-score and risk of being affected by overweight/obesity, respectively.
RESULTS: Higher triglyceride levels at less than 20 and 24-29 weeks of pregnancy were associated with higher body mass index z-scores (beta = 0.23; 95% CI: 0.07-0.38 and beta = 0.15; 95% CI: 0.01-0.29; respectively) after adjusting for confounders. There was no evidence of an association between total or low-density lipoprotein cholesterol and child weight status at age 3.
CONCLUSIONS: Early childhood body mass index may be influenced by maternal triglyceride levels during pregnancy.
URL
http://dx.doi.org/10.1111/ijpo.12485Reference Type
Journal ArticleYear Published
2019Journal Title
Pediatric ObesityAuthor(s)
Martin, Chantel L.Vladutiu, Catherine J.
Zikry, Tarek M.
Grace, Matthew R.
Siega-Riz, Anna Maria