Light at Night and the Risk of Breast Cancer: Findings from the Sister Study

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Citation

Sweeney, Marina R.; Nichols, Hazel B.; Jones, Rena R.; Olshan, Andrew F.; Keil, Alexander P.; Engel, Lawrence S.; James, Peter; Jackson, Chandra L.; Sandler, Dale P.; & White, Alexandra J. (2022). Light at Night and the Risk of Breast Cancer: Findings from the Sister Study. Environment International, 169, 107495. PMCID: PMC9561075

Abstract

BACKGROUND: Light at night (LAN) may alter estrogen regulation through circadian disruption. High levels of outdoor LAN may increase breast cancer risk, but studies have largely not considered possible residual confounding from correlated environmental exposures. We evaluated the association between indoor and outdoor LAN and incident breast cancer.
METHODS: In 47,145 participants in the prospective Sister Study cohort living in the contiguous U.S., exposure to outdoor LAN was determined using satellite-measured residential data and indoor LAN was self-reported (light/TV on, light from outside the room, nightlight, no light). We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between outdoor and indoor LAN and breast cancer risk. Models were adjusted for age, race/ethnicity, educational attainment, annual household income, neighborhood disadvantage, latitude, and population density as a proxy for urbanicity. To evaluate the potential for residual confounding of the outdoor LAN and breast cancer relationship by factors associated with urbanicity, we considered further adjustment for exposures correlated with outdoor LAN including NO(2) [Spearman correlation coefficient, rho (

URL

http://dx.doi.org/10.1016/j.envint.2022.107495

Reference Type

Journal Article

Year Published

2022

Journal Title

Environment International

Author(s)

Sweeney, Marina R.
Nichols, Hazel B.
Jones, Rena R.
Olshan, Andrew F.
Keil, Alexander P.
Engel, Lawrence S.
James, Peter
Jackson, Chandra L.
Sandler, Dale P.
White, Alexandra J.

Article Type

Regular

PMCID

PMC9561075

Data Set/Study

Sister Study

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Native American
Asian
African-American
White

Sex/Gender

Women

ORCiD

Olshan - 0000-0001-9115-5128