Citation
Van Velzen, Laura S.; Dauvermann, Maria R.; Colic, Lejla; Villa, Luca M.; Savage, Hannah S.; Toenders, Yara J.; Zhu, Alyssa H.; Bright, Joanna K.; Campos, Adrián I.; & Salminen, Lauren E., et al. (2022). Structural Brain Alterations Associated with Suicidal Thoughts and Behaviors in Young People: Results from 21 International Studies from the Enigma Suicidal Thoughts and Behaviours Consortium. Molecular Psychiatry, 27(11), 4550-4560. PMCID: PMC9734039Abstract
Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen’s d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.URL
https://doi.org/10.1038/s41380-022-01734-0Reference Type
Journal ArticleYear Published
2022Journal Title
Molecular PsychiatryAuthor(s)
Van Velzen, Laura S.Dauvermann, Maria R.
Colic, Lejla
Villa, Luca M.
Savage, Hannah S.
Toenders, Yara J.
Zhu, Alyssa H.
Bright, Joanna K.
Campos, Adrián I.
Salminen, Lauren E.
Ambrogi, Sonia
Ayesa-Arriola, Rosa
Banaj, Nerisa
Ba
şg
öze, Zeynep
Bauer, Jochen
Blair, Karina
Blair, Robert James
Brosch, Katharina
Cheng, Yuqi
Colle, Romain
Connolly, Colm G.
Corruble, Emmanuelle
Couvy-Duchesne, Baptiste
Crespo-Facorro, Benedicto
Cullen, Kathryn R.
Dannlowski, Udo
Davey, Christopher G.
Dohm, Katharina
Fullerton, Janice M.
Gonul, Ali Saffet
Gotlib, Ian H.
Grotegerd, Dominik
Hahn, Tim
Harrison, Ben J.
He, Mengxin
Hickie, Ian B.
Ho, Tiffany C.
Iorfino, Frank
Jansen, Andreas
Jollant, Fabrice
Kircher, Tilo
Klimes-Dougan, Bonnie
Klug, Melissa
Leehr, Elisabeth J.
Lippard, Elizabeth T. C.
McLaughlin, Katie A.
Meinert, Susanne
Miller, Adam Bryant
Mitchell, Philip B.
Mwangi, Benson
Nenadi
ć, Igor
Ojha, Amar
Overs, Bronwyn J.
Pfarr, Julia-Katharina
Piras, Fabrizio
Ringwald, Kai G.
Roberts, Gloria
Romer, Georg
Sanches, Marsal
Sheridan, Margaret A.
Soares, Jair C.
Spalletta, Gianfranco
Stein, Frederike
Teresi, Giana I.
Tordesillas-Guti
érrez, Diana
Uyar-Demir, Aslihan
van der Wee, Nic J. A.
van der Werff, Steven J.
Vermeiren, Robert R. J. M.
Winter, Alexandra
Wu, Mon-Ju
Yang, Tony T.
Thompson, Paul M.
Rentería, Miguel E.
Jahanshad, Neda
Blumberg, Hilary P.
van Harmelen, Anne-Laura
van Velzen, Laura S.
van der Wee, Nic J. A.
van der Werff, Steven J.
van Harmelen, Anne-Laura
Schmaal, Lianne