Citation
O'Shea, Michael; Register, Hannah M.; Yi, Joe X.; Jensen, Elizabeth T.; Joseph, Robert M.; Kuban, Karl C. K.; Frazier, Jean A.; Washburn, Lisa; Belfort, Mandy; & South, Andrew M., et al. (2023). Growth during Infancy after Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes. Journal of Pediatrics, 252, 40-47. PMCID: PMC10242541Abstract
OBJECTIVE: To evaluate associations between changes in weight, length, and weight/length ratio during infancy and outcomes later in life among individuals born extremely preterm.STUDY DESIGN: Among participants in the Extremely Low Gestational Age Newborn Study, we measured weight and length at discharge from neonatal intensive care and at 2 years of age and evaluated neurocognitive, psychiatric, and health outcomes at 10 and 15 years of age. Using multivariable logistic regression we estimated associations between gains in weight, length, and weight/length ratio z-scores between discharge and 2 years and outcomes at 10 and 15 years. High gain was defined as top quintile change; low gain, as bottom quintile.
RESULTS: High gains in weight and weight/length were associated with higher odds of obesity at 10, but not 15 years. These associations were found only for females. High gain in length z-score was associated with lower odds of obesity at 15 years. The only association found between high gains in growth measures and more favorable neurocognitive or psychiatric outcomes was between high gain in weight/length and lower odds of cognitive impairment at 10 years.
CONCLUSION: During the two years after NICU discharge, females born extremely preterm infants with high gains in weight/length or weight, have higher odds of obesity at 10, but not at 15, years. Infants with high growth gains in the two years after NICU discharge have neurocognitive and psychiatric outcomes in middle childhood and adolescence that are similar to those of infants with lower gains in weight and weight/length.
URL
http://dx.doi.org/10.1016/j.jpeds.2022.08.015Reference Type
Journal ArticleYear Published
2023Journal Title
Journal of PediatricsAuthor(s)
O'Shea, MichaelRegister, Hannah M.
Yi, Joe X.
Jensen, Elizabeth T.
Joseph, Robert M.
Kuban, Karl C. K.
Frazier, Jean A.
Washburn, Lisa
Belfort, Mandy
South, Andrew M.
Santos, Hudson P. Jr.
Shenberger, Jeffrey
Perrin, Eliana M.
Thompson, Amanda L.
Singh, Rachana
Rollins, Julie
Gogcu, Semsa
Sanderson, Keia
Wood, Charles T.
Fry, Rebecca C.