Citation
Anderson, Chelsea; Olshan, Andrew F.; Park, Jihye; Bae-Jump, Victoria L.; Brewster, Wendy R.; Lund, Jennifer L.; & Nichols, Hazel B. (2022). Adverse Urinary System Diagnoses among Older Women with Endometrial Cancer. Cancer Epidemiology, Biomarkers & Prevention, 31(7), 1368-1375.Abstract
BACKGROUND: Endometrial cancer and its treatment may impact urinary system function, but few large-scale studies have examined urinary diagnoses among endometrial cancer survivors. We investigated the risk of several urinary outcomes among older women with endometrial cancer compared with similar women without a cancer history.METHODS: Women aged 66+ years with an endometrial cancer diagnosis during 2004-2017 (N = 44,386) and women without a cancer history (N = 221,219) matched 1:5 on exact age, race/ethnicity, and state were identified in the Surveillance, Epidemiology, and End Results-Medicare linked data. ICD-9 and -10 diagnosis codes were used to define urinary outcomes in the Medicare claims. HRs for urinary outcomes were estimated using multivariable Cox proportional hazards regression models.
RESULTS: Relative to women without cancer, endometrial cancer survivors were at an increased risk of several urinary system diagnoses, including lower urinary tract infection [HR, 2.36; 95% confidence interval (CI), 2.32-2.40], urinary calculus (HR, 2.22; 95% CI, 2.13-2.31), renal failure (HR, 2.28; 95% CI, 2.23-2.33), and chronic kidney disease (HR, 1.85; 95% CI, 1.81-1.90). Similar associations were observed in sensitivity analyses limited to 1+ and 5+ years after endometrial cancer diagnosis. Black race, higher comorbidity index, higher stage or grade cancer, non-endometrioid histology, and treatment with chemotherapy and/or radiation were often significant predictors of urinary outcomes among endometrial cancer survivors.
CONCLUSIONS: Our results suggest that, among older women, the risk of urinary outcomes is elevated after endometrial cancer.
IMPACT: Monitoring for urinary diseases may be a critical part of long-term survivorship care for older women with an endometrial cancer history.
URL
http://dx.doi.org/10.1158/1055-9965.Epi-22-0236Reference Type
Journal ArticleYear Published
2022Journal Title
Cancer Epidemiology, Biomarkers & PreventionAuthor(s)
Anderson, ChelseaOlshan, Andrew F.
Park, Jihye
Bae-Jump, Victoria L.
Brewster, Wendy R.
Lund, Jennifer L.
Nichols, Hazel B.