Citation
Peters, Brandilyn A.; Lin, Juan; Qi, Qibin; Usyk, Mykhaylo; Isasi, Carmen R.; Mossavar-Rahmani, Yasmin; Derby, Carol A.; Santoro, Nanette; Perreira, Krista M.; & Daviglus, Martha L., et al. (2022). Menopause is Associated with an Altered Gut Microbiome and Estrobolome, with Implications for Adverse Cardiometabolic Risk in the Hispanic Community Health Study/Study of Latinos. mSystems, 7(3), e0027322. PMCID: PMC9239235Abstract
Menopause is a pivotal period during which loss of ovarian hormones increases cardiometabolic risk and may also influence the gut microbiome. However, the menopause-microbiome relationship has not been examined in a large study, and its implications for cardiometabolic disease are unknown. In the Hispanic Community Health Study/Study of Latinos, a population with high burden of cardiometabolic risk factors, shotgun metagenomic sequencing was performed on stool from 2,300 participants (295 premenopausal women, 1,027 postmenopausal women, and 978 men), and serum metabolomics was available on a subset. Postmenopausal women trended toward lower gut microbiome diversity and altered overall composition compared to premenopausal women, while differing less from men, in models adjusted for age and other demographic/behavioral covariates. Differentially abundant taxa for post- versus premenopausal women included Bacteroides sp. strain Ga6A1, Prevotella marshii, and Sutterella wadsworthensis (enriched in postmenopause) and Escherichia coli-Shigella spp., Oscillibacter sp. strain KLE1745, Akkermansia muciniphila, Clostridium lactatifermentans, Parabacteroides johnsonii, and Veillonella seminalis (depleted in postmenopause); these taxa similarly differed between men and women. Postmenopausal women had higher abundance of the microbial sulfate transport system and decreased abundance of microbialURL
http://dx.doi.org/10.1128/msystems.00273-22Reference Type
Journal ArticleYear Published
2022Journal Title
mSystemsAuthor(s)
Peters, Brandilyn A.Lin, Juan
Qi, Qibin
Usyk, Mykhaylo
Isasi, Carmen R.
Mossavar-Rahmani, Yasmin
Derby, Carol A.
Santoro, Nanette
Perreira, Krista M.
Daviglus, Martha L.
Kominiarek, Michelle A.
Cai, Jianwen
Knight, Rob
Burk, Robert D.
Kaplan, Robert C.