Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence from a Chilean Infancy Cohort

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Citation

Von Holle, Ann F.; North, Kari E.; Gahagan, Sheila; Blanco, Estela; Burrows, Raquel A.; Lozoff, Betsy; Howard, Annie Green; Justice, Anne E.; Graff, Mariaelisa; & Voruganti, Saroja (2022). Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence from a Chilean Infancy Cohort. American Journal of Epidemiology, 191(10), 1700-1709. PMCID: PMC9989340

Abstract

Growth in early infancy is hypothesized to affect chronic disease risk factors later in life. To date, most reports draw on European ancestry cohorts with few repeated observations in early infancy. We investigated the association between infant growth before six months and lipid levels in adolescents in a Hispanic/Latino cohort. We characterized infant growth from birth to five months in males (n=311) and females (n=285) from the Santiago Longitudinal Study (1991-1996) using three metrics: weight (kg), length (cm) and weight-for-length (WFL) (g/cm). SuperImposition by Translation and Rotation (SITAR) and latent growth mixture models (LGMM) were used to estimate the association between infant growth characteristics and lipid levels at 17 years. We found a positive relationship between the SITAR length velocity parameter before six months of age and high-density lipoprotein cholesterol levels in adolescence (11.5, standard error=4.1) indicating higher high-density lipoprotein cholesterol levels occurring with faster length growth. The strongest associations from the LGMM models were between higher low-density lipoprotein cholesterol and slower WFL growth, following a pattern of associations between slower growth and adverse lipid profiles. Further research in this window of time can confirm the association between early infant growth as an exposure and adolescent cardiovascular disease risk factors.

URL

http://dx.doi.org/10.1093/aje/kwac057

Reference Type

Journal Article

Year Published

2022

Journal Title

American Journal of Epidemiology

Author(s)

Von Holle, Ann F.
North, Kari E.
Gahagan, Sheila
Blanco, Estela
Burrows, Raquel A.
Lozoff, Betsy
Howard, Annie Green
Justice, Anne E.
Graff, Mariaelisa
Voruganti, Saroja

Article Type

Regular

PMCID

PMC9989340

Data Set/Study

Santiago Longitudinal Study

Continent/Country

Chile

Race/Ethnicity

Hispanic/Latinx

ORCiD

Howard, AG - 0000-0003-0837-8166
Graff - 0000-0001-6380-1735