Citation
Bravi, Francesca; Lee, Yuan-Chin Amy; Hashibe, Mia; Boffetta, Paolo; Conway, David I.; Ferraroni, Monica; La Vecchia, Carlo; Edefonti, Valeria; Agudo, Antonio; & Ahrens, Wolfgang, et al. (2021). Lessons Learned from the INHANCE Consortium: An Overview of Recent Results on Head and Neck Cancer. Oral Diseases, 27(1), 73-93. PMCID: PMC7752834Abstract
OBJECTIVE: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium.SUBJECTS AND METHODS: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview.
RESULTS: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively.
CONCLUSIONS: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
URL
http://dx.doi.org/10.1111/odi.13502Reference Type
Journal ArticleYear Published
2021Journal Title
Oral DiseasesAuthor(s)
Bravi, FrancescaLee, Yuan-Chin Amy
Hashibe, Mia
Boffetta, Paolo
Conway, David I.
Ferraroni, Monica
La Vecchia, Carlo
Edefonti, Valeria
Agudo, Antonio
Ahrens, Wolfgang
Benhamou, Simone
Boccia, Stefania
Brennan, Paul
Brenner, Hermann
Cadoni, Gabriella
Canova, Cristina
Chen, Chu
Chuang, Shu-Chun
Curado, Maria Paula
Dal Maso, Luigino
Daudt, Alexander W.
D'Souza, Gypsyamber
Fabianova, Eleonora
Fernandez, Leticia
Franceschi, Silvia
Garavello, Werner
Gillison, Maura L.
Gross, Neil D.
Hayes, Richard B.
Healy, Claire M.
Herrero, Rolando
Holcatova, Ivana
Kelsey, Karl T.
Kjaerheim, Kristina
Koifman, Rosalina
Lagiou, Pagona
Lazarus, Philip
Levi, Fabio
Li, Guojun
Lissowska, Jolanta
Luce, Daniele
Macfarlane, Gary J.
Mates, Dana
Matsuo, Keitaro
McClean, Michael D.
Menezes, Ana M.
Menvielle, Gwenn
Morgenstern, Hal
Moyses, Raquel A.
Moysich, Kirsten
Muscat, Joshua E.
Negri, Eva
Olshan, Andrew F.
Pandics, Tamas
Polesel, Jerry
Purdue, Mark P.
Radoï, Loredana
Ramroth, Heribert
Richiardi, Lorenzo
Schantz, Stimson
Schwartz, Stephen M.
Serraino, Diego
Shangina, Oxana
Smith, Elaine
Sturgis, Erich M.
Świątkowska,
Beata
Thomson, Peter
Toporcov, Tatiana N.
Vaughan, Thomas L
.
Vilensky, Marta
Winn, Deborah M.
Wunsch-Filho,
Victor
Yu,
Guo-Pei
Zevallos, Jose P
.
Zhang, Zuo-Feng
Zheng, Tongzhang
Znaor
,
Ariana