Determinants and Trends of COVID-19 Vaccine Hesitancy and Vaccine Uptake in a National Cohort of U.S. Adults: A Longitudinal Study

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Citation

Rane, Madhura; Kochhar, Shivani; Poehlein, Emily; You, William; Robertson, McKaylee; Zimba, Rebecca; Westmoreland, Drew; Romo, Matthew L.; Kulkarni, Sarah Gorrell; & Chang, Mindy, et al. (2022). Determinants and Trends of COVID-19 Vaccine Hesitancy and Vaccine Uptake in a National Cohort of U.S. Adults: A Longitudinal Study. American Journal of Epidemiology, 191(4), 570-583. PMCID: PMC8755394

Abstract

We estimated the trends and correlates of vaccine hesitancy, and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the CHASING COVID Cohort, a national longitudinal study. Trends and correlates of vaccine hesitancy were examined longitudinally in eight interview rounds from October 2020 to July 2021. We also estimated the association between willingness to vaccinate and subsequent vaccine uptake through July 2021. Vaccine delay and refusal decreased from 51% and 8% in October 2020 to 8% and 6% in July 2021, respectively. Compared to Non-Hispanic (NH) White participants, NH Black and Hispanic participants had higher adjusted odds ratios (aOR) for both vaccine delay (aOR: 2.0 [95% CI: 1.5, 2.7] for NH Black and 1.3 [95% CI: 1.0, 1.7] for Hispanic) and vaccine refusal (aOR: 2.5 [95% CI: 1.8, 3.6] for NH Black and 1.4 [95% CI: 1.0, 2.0] for Hispanic) in June 2021. COVID-19 vaccine hesitancy was associated with lower odds of subsequent vaccine uptake (aOR: 0.15, 95% CI: 0.13, 0.18 for vaccine-delayers and aOR: 0.02; 95% CI: 0.01, 0.03 for vaccine-refusers compared to vaccine-willing participants), adjusted for sociodemographic factors and COVID-19 history. Vaccination awareness and distribution efforts should focus on vaccine delayers.

URL

http://dx.doi.org/10.1093/aje/kwab293

Reference Type

Journal Article

Year Published

2022

Journal Title

American Journal of Epidemiology

Author(s)

Rane, Madhura
Kochhar, Shivani
Poehlein, Emily
You, William
Robertson, McKaylee
Zimba, Rebecca
Westmoreland, Drew
Romo, Matthew L.
Kulkarni, Sarah Gorrell
Chang, Mindy
Berry, Amanda
Parcesepe, Angela M.
Maroko, Andrew R.
Grov, Christian
Nash, Denis

Article Type

Regular

PMCID

PMC8755394

Data Set/Study

Communities, Households and SARS/CoV-2 Epidemiology (CHASING) COVID Cohort Study

Continent/Country

United States of America

State

Nonspecific

ORCiD

Parcesepe - 0000-0002-4321-125x