Citation
Pippen, Jessica; Stetson, Bethany; Doherty, Lindsay; Varner, Michael W.; Casey, Brian M.; Reddy, Uma M.; Wapner, Ronald J.; Rouse, Dwight J.; Tita, Alan T. N.; & Thorp, John M., Jr., et al. (2022). Neonatal Birthweight, Infant Feeding, and Childhood Metabolic Markers. American Journal of Perinatology, 39(6), 584-591. PMCID: PMC9106839Abstract
OBJECTIVE: Antenatal and early neonatal nutritional environment may influence later metabolic health. Infants of mothers with gestational diabetes mellitus (GDM) have higher risk for childhood obesity and metabolic syndrome (MetS). Leptin and adiponectin are known biomarkers for MetS and may guide interventions to reduce later obesity. We sought to examine the relationship between birthweight, early infancy feeding practices, and biomarkers for MetS in offspring of women with mild GDM.STUDY DESIGN: Secondary analysis of a prospective observational follow-up study on the offspring of women who participated in a multicenter randomized treatment trial on mild GDM. Children were evaluated by research coordinators and biospecimens collected at the age of 5 to 10. Plasma concentrations of leptin and adiponectin were compared between large for gestational age (LGA) and average birthweight (AGA) infants, and according to whether solid foods were introduced early (<6 months of age) or at the recommended age (
URL
http://dx.doi.org/10.1055/s-0041-1740056Reference Type
Journal ArticleYear Published
2022Journal Title
American Journal of PerinatologyAuthor(s)
Pippen, JessicaStetson, Bethany
Doherty, Lindsay
Varner, Michael W.
Casey, Brian M.
Reddy, Uma M.
Wapner, Ronald J.
Rouse, Dwight J.
Tita, Alan T. N.
Thorp, John M., Jr.
Chien, Edward K.
Saade, George R.
Blackwell, Sean C.