Resource Profile and User Guide of the Polygenic Index Repository

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Citation

Becker, Joel; Burik, Casper A. P.; Goldman, Grant; Wang, Nancy; Jayashankar, Hariharan; Bennett, Michael; Belsky, Daniel W.; Karlsson Linnér, Richard; Ahlskog, Rafael; & Kleinman, Aaron, et al. (2021). Resource Profile and User Guide of the Polygenic Index Repository. Nature Human Behavior, 5(12), 1744-1758. PMCID: PMC8678380

Abstract

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the PGIs' prediction accuracies, we constructed them using genome-wide association studies-some not previously published-from multiple data sources, including 23andMe and UK Biobank. We present a theoretical framework to help interpret analyses involving PGIs. A key insight is that a PGI can be understood as an unbiased but noisy measure of a latent variable we call the 'additive SNP factor'. Regressions in which the true regressor is this factor but the PGI is used as its proxy therefore suffer from errors-in-variables bias. We derive an estimator that corrects for the bias, illustrate the correction, and make a Python tool for implementing it publicly available.

URL

http://dx.doi.org/10.1038/s41562-021-01119-3

Reference Type

Journal Article

Year Published

2021

Journal Title

Nature Human Behavior

Author(s)

Becker, Joel
Burik, Casper A. P.
Goldman, Grant
Wang, Nancy
Jayashankar, Hariharan
Bennett, Michael
Belsky, Daniel W.
Karlsson Linnér, Richard
Ahlskog, Rafael
Kleinman, Aaron
Hinds, David A.
23andMe Research Team,
Caspi, Avshalom
Corcoran, David L.
Moffitt, Terrie E.
Poulton, Richie
Sugden, Karen
Williams, Benjamin S.
Harris, Kathleen Mullan
Steptoe, Andrew
Ajnakina, Olesya
Milani, Lili
Esko, Tõnu
Iacono, William G.
McGue, Matt
Magnusson, Patrik K. E.
Mallard, Travis T.
Harden, K. Paige
Tucker-Drob, Elliot M.
Herd, Pamela
Freese, Jeremy
Young, Alexander
Beauchamp, Jonathan P.
Koellinger, Philipp D.
Oskarsson, Sven
Johannesson, Magnus
Visscher, Peter M.
Meyer, Michelle N.
Laibson, David I.
Cesarini, David
Benjamin, Daniel J.
Turley, Patrick
Okbay, Aysu

Article Type

Regular

PMCID

PMC8678380

Data Set/Study

23andMe
UK Biobank Study

ORCiD

Harris, KM - 0000-0001-9757-1026