Impact of Paternal Education on Epigenetic Ageing in Adolescence and Mid-Adulthood: A Multi-Cohort Study in the USA and Mexico

Citation

Joyce, Brian T.; Gao, Tao; Koss, Kalsea; Zheng, Yinan; Cardenas, Andres Heiss, Jonathan; Just, Allan C.; Zhang, Kai; van Horn, Linda V.; Allen, Norrina B.; & Greenland, Philip, et al. (2022). Impact of Paternal Education on Epigenetic Ageing in Adolescence and Mid-Adulthood: A Multi-Cohort Study in the USA and Mexico. International Journal of Epidemiology, 51(3), 870-884. PMCID: PMC9189973

Abstract

BACKGROUND: Both parental and neighbourhood socio-economic status (SES) are linked to poorer health independently of personal SES measures, but the biological mechanisms are unclear. Our objective was to examine these influences via epigenetic age acceleration (EAA)-the discrepancy between chronological and epigenetic ages.
METHODS: We examined three USA-based [Coronary Artery Risk Disease in Adults (CARDIA) study, Fragile Families and Child Wellbeing Study (FFCWS) and Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS)] and one Mexico-based (Project Viva) cohort. DNA methylation was measured using Illumina arrays, personal/parental SES by questionnaire and neighbourhood disadvantage from geocoded address. In CARDIA, we examined the most strongly associated personal, parental and neighbourhood SES measures with EAA (Hannum's method) at study years 15 and 20 separately and combined using a generalized estimating equation (GEE) and compared with other EAA measures (Horvath's EAA, PhenoAge and GrimAge calculators, and DunedinPoAm).
RESULTS: EAA was associated with paternal education in CARDIA [GEEs:

URL

http://dx.doi.org/10.1093/ije/dyab196

Reference Type

Journal Article

Year Published

2022

Journal Title

International Journal of Epidemiology

Author(s)

Joyce, Brian T.
Gao, Tao
Koss, Kalsea
Zheng, Yinan
Cardenas, Andres Heiss, Jonathan
Just, Allan C.
Zhang, Kai
van Horn, Linda V.
Allen, Norrina B.
Greenland, Philip
Cohen, Sheldon
Gordon-Larsen, Penny
Mitchell, Colter
McLanahan, Sara L.
Schneper, Lisa
Notterman, Daniel
Rifas-Shiman, Sheryl L.
Oken, Emily
Hivert, Marie-France
Wright, Robert
Baccarelli, Andrea A.
Lloyd-Jones, Donald M.
Hou, Lifang

Article Type

Regular

PMCID

PMC9189973

Data Set/Study

Coronary Artery Risk Development in Young Adults (CARDIA) Study
Fragile Families and Child Wellbeing Study (FFCWS)
Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS)
Project Viva

Continent/Country

North America

ORCiD

Gordon-Larsen - 0000-0001-5322-4188