Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results from Posttraumatic Stress Disorder Consortia

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Citation

Logue, Mark W.; van Rooij, Sanne J. H.; Dennis, Emily L.; Davis, Sarah L.; Hayes, Jasmeet P.; Stevens, Jennifer S.; Densmore, Maria; Haswell, Courtney C.; Ipser, Jonathan; & Koch, Saskia B. J., et al. (2018). Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results from Posttraumatic Stress Disorder Consortia. Biological Psychiatry, 83(3), 244-253. PMCID: PMC5951719

Abstract

BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group.
METHODS: We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium.
RESULTS: In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063).
CONCLUSIONS: Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

URL

http://dx.doi.org/10.1016/j.biopsych.2017.09.006

Reference Type

Journal Article

Year Published

2018

Journal Title

Biological Psychiatry

Author(s)

Logue, Mark W.
van Rooij, Sanne J. H.
Dennis, Emily L.
Davis, Sarah L.
Hayes, Jasmeet P.
Stevens, Jennifer S.
Densmore, Maria
Haswell, Courtney C.
Ipser, Jonathan
Koch, Saskia B. J.
Korgaonkar, Mayuresh
Lebois, Lauren A. M.
Peverill, Matthew R.
Baker, Justin T.
Boedhoe, Premika S. W.
Frijling, Jessie L.
Gruber, Staci A.
Harpaz-Rotem, Ilan
Jahanshad, Neda
Koopowitz, Sheri
Levy, Ifat
Nawijn, Laura
O'Connor, Lauren
Olff, Miranda
Salat, David H.
Sheridan, Margaret A.
Spielberg, Jeffrey M.
van Zuiden, Mirjam
Winternitz, Sherry R.
Wolff, Jonathan D.
Wolf, Erika J.
Wang, Xin
Wrocklage, Kristen
Abdallah, Chadi G.
Bryant, Richard A.
Geuze, Elbert
Jovanovic, Tanja
Kaufman, Milissa L.
King, Anthony P.
Krystal, John H.
Lagopoulos, Jim
Bennett, Maxwell
Lanius, Ruth
Liberzon, Israel
McGlinchey, Regina E.
McLaughlin, Katie A.
Milberg, William P.
Miller, Mark W.
Ressler, Kerry J.
Veltman, Dick J.
Stein, Dan J.
Thomaes, Kathleen
Thompson, Paul M.
Morey, Rajendra A.

Article Type

Regular

PMCID

PMC5951719

Data Set/Study

Psychiatric Genomics Consortium [PGC]– Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group

Continent/Country

Netherlands
South Africa
United States of America
Australia
Canada

State

Nonspecific

ORCiD

Sheridan - 0000-0002-8909-7501