Citation
Bentley, Amy R.; Sung, Yun J.; Brown, Michael R.; Winkler, Thomas W.; Kraja, Aldi T.; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I.; Lim, Elise; & Deng, Xuan, et al. (2019). Multi-Ancestry Genome-Wide Gene-Smoking Interaction Study of 387,272 Individuals Identifies New Loci Associated with Serum Lipids. Nature Genetics, 51(4), 636-648. PMCID: PMC6467258Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.URL
http://dx.doi.org/10.1038/s41588-019-0378-yReference Type
Journal ArticleYear Published
2019Journal Title
Nature GeneticsAuthor(s)
Bentley, Amy R.Sung, Yun J.
Brown, Michael R.
Winkler, Thomas W.
Kraja, Aldi T.
Ntalla, Ioanna
Schwander, Karen
Chasman, Daniel I.
Lim, Elise
Deng, Xuan
Guo, Xiuqing
Liu, Jingmin
Lu, Yingchang
Cheng, Ching-Yu
Sim, Xueling
Vojinovic, Dina
Huffman, Jennifer E.
Musani, Solomon K.
Li, Changwei
Feitosa, Mary F.
Richard, Melissa A.
Noordam, Raymond
Baker, Jenna
Chen, Guanjie
Aschard, Hugues
Bartz, Traci M.
Ding, Jingzhong
Dorajoo, Rajkumar
Manning, Alisa K.
Rankinen, Tuomo
Smith, Albert V.
Tajuddin, Salman M.
Zhao, Wei
Graff, Mariaelisa
Alver, Maris
Boissel, Mathilde
Chai, Jin Fang
Chen, Xu
Divers, Jasmin
Evangelou, Evangelos
Gao, Chuan
Goel, Anuj
Hagemeijer, Yanick
Harris, Sarah E.
Hartwig, Fernando Pires
He, Meian
Horimoto, Andrea R. V. R.
Hsu, Fang-Chi
Hung, Yi-Jen
Jackson, Anne U.
Kasturiratne, Anuradhani
Komulainen, Pirjo
Kuhnel, Brigitte
Leander, Karin
Lin, Keng-Hung
Luan, Jian'an
Lyytikainen, Leo-Pekka
Matoba, Nana
Nolte, Ilja M.
Pietzner, Maik
Prins, Bram Peter
Riaz, Muhammad
Robino, Antonietta
Said, M. Abdullah
Schupf, Nicole
Scott, Robert A.
Sofer, Tamar
Stancakova, Alena
Takeuchi, Fumihiko
Tayo, Bamidele O.
van der Most, Peter J.
Varga, Tibor V.
Wang, Tzung-Dau
Wang, Yajuan
Ware, Erin B.
Wen, Wanqing
Xiang, Yong-Bing
Yanek, Lisa R.
Zhang, Weihua
Zhao, Jing Hua
Adeyemo, Adebowale A.
Afaq, Saima
Amin, Najaf
Amini, Marzyeh
Arking, Dan E.
Arzumanyan, Zorayr
Aung, Tin
Ballantyne, Christie M.
Barr, R. Graham
Bielak, Lawrence F.
Boerwinkle, Eric A.
Bottinger, Erwin P.
Broeckel, Ulrich
Brown, Morris J.
Cade, Brian E.
Campbell, Archie
Canouil, Mickael
Charumathi, Sabanayagam
Chen, Yii-Der Ida
Christensen, Kaare
COGENT-Kidney Consortium,
Concas, Maria Pina
Connell, John M.
de Las Fuentes, Lisa
de Silva, H. Janaka
de Vries, Paul S.
Doumatey, Ayo P.
Duan, Qing
Eaton, Charles B.
Eppinga, Ruben N.
Faul, Jessica D.
Floyd, James S.
Forouhi, Nita G.
Forrester, Terrence
Friedlander, Yechiel
Gandin, Ilaria
Gao, He
Ghanbari, Mohsen
Gharib, Sina A.
Gigante, Bruna
Giulianini, Franco
Grabe, Hans-Jorgen
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Harris, Tamara B.
Heikkinen, Sami
Heng, Chew-Kiat
Hirata, Makoto
Hixson, James E.
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EPIC-InterAct Consortium,
Jia, Yucheng
Joehanes, Roby
Johnson, Craig
Jonas, Jost B.
Justice, Anne E.
Katsuya, Tomohiro
Khor, Chiea Chuen
Kilpelainen, Tuomas O.
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Kolcic, Ivana
Kooperberg, Charles L.
Krieger, Jose E.
Kritchevsky, Stephen B.
Kubo, Michiaki
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Lakka, Timo A.
Langefeld, Carl D.
Langenberg, Claudia
Launer, Lenore J.
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Li, Yize
Liang, Jingjing
Lin, Shiow
Liu, Ching-Ti
Liu, Jianjun
Liu, Kiang
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Lohman, Kurt K.
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Luzzi, Anna
Magi, Reedik
Mahajan, Anubha
Manichaikul, Ani
McKenzie, Colin A.
Meitinger, Thomas
Metspalu, Andres
Milaneschi, Yuri
Milani, Lili
Mohlke, Karen L.
Momozawa, Yukihide
Morris, Andrew P.
Murray, Alison D.
Nalls, Mike A.
Nauck, Matthias
Nelson, Christopher P.
North, Kari E.
O'Connell, Jeffrey R.
Palmer, Nicholette D.
Papanicolaou, George J.
Pedersen, Nancy L.
Peters, Annette
Peyser, Patricia A.
Polasek, Ozren
Poulter, Neil
Raitakari, Olli T.
Reiner, Alexander P.
Renstrom, Frida
Rice, Treva K.
Rich, Stephen S.
Robinson, Jennifer G.
Rose, Lynda M.
Rosendaal, Frits R.
Rudan, Igor
Schmidt, Carsten O.
Schreiner, Pamela J.
Scott, William R.
Sever, Peter
Shi, Yuan
Sidney, Stephen
Sims, Mario
Smith, Jennifer A.
Snieder, Harold
Starr, John M.
Strauch, Konstantin
Stringham, Heather M.
Tan, Nicholas X.
Tang, Hua
Taylor, Kent D.
Teo, Yik Ying
Tham, Yih Chung
Tiemeier, Henning
Turner, Stephen T.
Uitterlinden, Andre G.
Understanding Society Scientific Group,
van Heemst, Diana
Waldenberger, Melanie
Wang, Heming
Wang, Lan
Wang, Lihua
Wei, Wen Bin
Williams, Christine A.
Wilson, Gregory, Sr.
Wojczynski, Mary K.
Yao, Jie
Young, Kristin L.
Yu, Caizheng
Yuan, Jian-Min
Zhou, Jie
Zonderman, Alan B.
Becker, Diane M.
Boehnke, Michael
Bowden, Donald W.
Chambers, John C.
Cooper, Richard S.
de Faire, Ulf
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Esko, Tonu
Farrall, Martin
Franks, Paul W.
Freedman, Barry I.
Froguel, Philippe
Gasparini, Paolo
Gieger, Christian
Horta, Bernardo L.
Juang, Jyh-Ming J.
Kamatani, Yoichiro
Kammerer, Candace M.
Kato, Norihiro
Kooner, Jaspal Singh S.
Laakso, Markku
Laurie, Cathy C.
Lee, I-Te
Lehtimaki, Terho
Lifelines Cohort Study,
Magnusson, Patrik K. E.
Oldehinkel, Albertine J.
Penninx, Brenda W. J. H. W.
Pereira, Alexandre C.
Rauramaa, Rainer
Redline, Susan S.
Samani, Nilesh J.
Scott, James
Shu, Xiao-Ou
van der Harst, Pim
Wagenknecht, Lynne E.
Wang, Jun-Sing
Wang, Ya Xing
Wareham, Nicholas J.
Watkins, Hugh
Weir, David R.
Wickremasinghe, Ananda R.
Wu, Tangchun
Zeggini, Eleftheria
Zheng, Wei
Bouchard, Claude
Evans, Michele K.
Gudnason, Vilmundur G.
Kardia, Sharon L. R.
Liu, Yongmei
Psaty, Bruce M.
Ridker, Paul M.
van Dam, Rob M.
Mook-Kanamori, Dennis O.
Fornage, Myriam
Province, Michael A.
Kelly, Tanika N.
Fox, Ervin R.
Hayward, Caroline
van Duijn, Cornelia M.
Tai, E. Shyong
Wong, Tien Yin
Loos, Ruth J. F.
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Rotter, Jerome I.
Zhu, Xiaofeng
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Gauderman, W. James
Rice, Kenneth M.
Munroe, Patricia B.
Morrison, Alanna C.
Rao, Dabeeru C.
Rotimi, Charles N.
Cupples, L. Adrienne