Citation
Jiang, Xia; Finucane, Hilary; Schumacher, Fredrick R.; Schmit, Stephanie L.; Tyrer, Jonathan P.; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B.; & Dennis, Joe G., et al. (2019). Shared Heritability and Functional Enrichment across Six Solid Cancers. Nature Communications, 10, 431. PMCID: PMC6347624Abstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 × 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 × 10(-5)), breast and lung cancer (r(g) = 0.18, p =1.5 × 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 × 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.URL
http://dx.doi.org/10.1038/s41467-018-08054-4Reference Type
Journal ArticleYear Published
2019Journal Title
Nature CommunicationsAuthor(s)
Jiang, XiaFinucane, Hilary
Schumacher, Fredrick R.
Schmit, Stephanie L.
Tyrer, Jonathan P.
Han, Younghun
Michailidou, Kyriaki
Lesseur, Corina
Kuchenbaecker, Karoline B.
Dennis, Joe G.
Conti, David V.
Casey, Graham
Gaudet, Mia M.
Huyghe, Jeroen R.
Albanes, Demetrius
Aldrich, Melinda C.
Andrew, Angeline S.
Andrulis, Irene L.
Anton-Culver, Hoda
Antoniou, Antonis C.
Antonenkova, Natalia N.
Arnold, Susanne M.
Aronson, Kristan J.
Arun, Banu K.
Bandera, Elisa V.
Barkardottir, Rosa B.
Barnes, Daniel R.
Batra, Jyotsna
Beckmann, Matthias W.
Benitez, Javier
Benlloch, Sara
Berchuck, Andrew
Berndt, Sonja I.
Bickeböller, Heike
Bien, Stephanie A.
Blomqvist, Carl
Boccia, Stefania
Bogdanova, Natalia V.
Bojesen, Stig Egil
Bolla, Manjeet K.
Brauch, Hiltrud
Brenner, Hermann
Brenton, James D.
Brook, Mark N.
Brunet, Joan
Brunnström, Hans
Buchanan, Daniel D.
Burwinkel, Barbara
Butzow, Ralf
Cadoni, Gabriella
Caldés, Trinidad
Caligo, Maria A.
Campbell, Ian G.
Campbell, Peter T.
Cancel-Tassin, Géraldine
Cannon-Albright, Lisa A.
Campa, Daniele
Caporaso, Neil E.
Carvalho, Andre Lopes
Chan, Andrew T.
Chang-Claude, Jenny
Chanock, Stephen J.
Chen, Chu
Christiani, David C.
Claes, Kathleen B. M.
Claessens, Frank
Clements, Judith
Collée, J. Margriet
Correa, Marcia Cruz
Couch, Fergus J.
Cox, Angela
Cunningham, Julie M.
Cybulski, Cezary
Czene, Kamila
Daly, Mary B.
deFazio, Anna
Devilee, Peter
Diez, Orland
Gago-Dominguez, Manuela
Donovan, Jenny L.
Dörk, Thilo
Duell, Eric J.
Dunning, Alison M.
Dwek, Miriam
Eccles, Diana M.
Edlund, Christopher K.
Edwards, Digna R. Velez
Ellberg, Carolina
Evans, D. Gareth
Fasching, Peter A.
Ferris, Robert L.
Liloglou, Triantafillos
Figueiredo, Jane C.
Fletcher, Olivia
Fortner, Renée Turzanski
Fostira, Florentia
Franceschi, Silvia
Friedman, Eitan
Gallinger, Steven J.
Ganz, Patricia A.
Garber, Judy
García-Sáenz, José A.
Gayther, Simon A.
Giles, Graham G.
Godwin, Andrew K.
Goldberg, Mark S.
Goldgar, David E.
Goode, Ellen L.
Goodman, Marc T.
Goodman, Gary E.
Grankvist, Kjell
Greene, Mark H.
Gronberg, Henrik
Gronwald, Jacek
Guénel, Pascal
Håkansson, Niclas
Hall, Per
Hamann, Ute
Hamdy, Freddie C.
Hamilton, Robert J.
Hampe, Jochen
Haugen, Aage
Heitz, Florian
Herrero, Rolando
Hillemanns, Peter
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Høgdall, Estrid
Hong, Yun-Chul
Hopper, John L.
Houlston, Richard S.
Hulick, Peter J.
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Imyanitov, Evgeny N.
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Kibel, Adam S.
Kiemeney, Lambertus A.
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Lejbkowicz, Flavio
Lenz, Heinz-Josef
Leslie, Goska
Lessel, Davor
Lester, Jenny
Levine, Douglas A.
Li, Li
Li, Christopher I.
Lindblom, Annika
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Liu, Geoffrey
Loupakis, Fotios
Lubiński, Jan
Maehle, Lovise
Maier, Christiane
Mannermaa, Arto
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Margolin, Sara
May, Taymaa
McGuffog, Lesley
Meindl, Alfons
Middha, Pooja
Miller, Austin
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Modugno, Francesmary
Montagna, Marco
Moreno, Victor
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Mucci, Lorelei
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Neuhausen, Susan L.
Nevanlinna, Heli
Newcomb, Polly A.
Newcomb, Lisa F.
Nielsen, Finn Cilius
Nikitina-Zake, Liene
Nordestgaard, Børge G.
Nussbaum, Robert L.
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Olopade, Olufunmilayo I.
Olshan, Andrew F.
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Pashayan, Nora
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Penney, Kathryn L.
Peters, Wilbert H. M.
Phelan, Catherine M.
Phipps, Amanda I.
Plaseska-Karanfilska, Dijana
Pring, Miranda
Prokofyeva, Darya
Radice, Paolo
Stefansson, Kari
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Raskin, Leon
Rennert, Gad
Rennert, Hedy S.
van Rensburg, Elizabeth J.
Riggan, Marjorie J.
Risch, Harvey A.
Risch, Angela
Roobol, Monique J.
Rosenstein, Barry S.
Rossing, Mary Anne
De Ruyck, Kim
Saloustros, Emmanouil
Sandler, Dale P.
Sawyer, Elinor J.
Schabath, Matthew B.
Schleutker, Johanna
Schmidt, Marjanka K.
Setiawan, V. Wendy
Shen, Hongbing
Siegel, Erin M.
Sieh, Weiva
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Slattery, Martha L.
Sorensen, Karina Dalsgaard
Southey, Melissa C.
Spurdle, Amanda B.
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Stintzing, Sebastian
Stone, Jennifer
Sundfeldt, Karin
Sutphen, Rebecca
Swerdlow, Anthony J.
Tajara, Eloiza H.
Tangen, Catherine M.
Tardon, Adonina
Taylor, Jack A.
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Teixeira, Manuel R.
Terry, Mary Beth
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Toland, Amanda E.
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Weissler, Mark Christian
Weitzel, Jeffrey N.
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White, Emily
Whittemore, Alice S.
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Wu, Anna H.
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Lindström, Sara