Citation
Williams, Lindsay A.; Hoadley, Katherine A.; Nichols, Hazel B.; Geradts, Joseph; Perou, Charles M.; Love, Michael I.; Olshan, Andrew F.; & Troester, Melissa A. (2019). Differences in Race, Molecular and Tumor Characteristics among Women Diagnosed with Invasive Ductal and Lobular Breast Carcinomas. Cancer Causes & Control, 30(1), 31-39. PMCID: PMC6396692Abstract
BACKGROUND: The dominant invasive breast cancer histologic subtype, ductal carcinoma, shows intrinsic subtype diversity. However, lobular breast cancers are predominantly Luminal A. Both histologic subtypes show distinct relationships with patient and tumor characteristics, but it is unclear if these associations remain after accounting for intrinsic subtype.METHODS: Generalized linear models were used to estimate relative frequency differences (RFDs) and 95% confidence intervals (95% CIs) for the associations between age, race, tumor characteristics, immunohistochemistry (IHC) and RNA-based intrinsic subtype, TP53 status, and histologic subtype in the Carolina Breast Cancer Study (CBCS, n = 3,182) and The Cancer Genome Atlas (TCGA, n = 808).
RESULTS: Relative to ductal tumors, lobular tumors were significantly more likely to be Luminal A [CBCS RNA RFD: 44.9%, 95% CI (39.6, 50.1); TCGA: RFD: 50.5%, 95% CI (43.9, 57.1)], were less frequent among young (CONCLUSIONS: While histology is strongly associated with molecular characteristics, histologic associations with age, race, size, grade, and stage persisted after restricting to Luminal A subtype. Histology may continue to be clinically relevant among Luminal A breast cancers.
URL
http://dx.doi.org/10.1007/s10552-018-1121-1Reference Type
Journal ArticleYear Published
2019Journal Title
Cancer Causes & ControlAuthor(s)
Williams, Lindsay A.Hoadley, Katherine A.
Nichols, Hazel B.
Geradts, Joseph
Perou, Charles M.
Love, Michael I.
Olshan, Andrew F.
Troester, Melissa A.