Determinants of Growth in HIV-Exposed and -Uninfected Infants in the Kabeho Study

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Citation

Lane, Charlotte E.; Bobrow, Emily A.; Ndatimana, Dieudonne; Ndayisaba, Gilles F.; & Adair, Linda S. (2019). Determinants of Growth in HIV-Exposed and -Uninfected Infants in the Kabeho Study. Maternal & Child Nutrition, 15(3), e12776. PMCID: PMC6667835

Abstract

HIV-exposed and -uninfected (HEU) infants may be at increased risk of poor health and growth outcomes. We characterized infant growth trajectories in a cohort of HEU infants to identify factors associated with healthy growth. HIV-positive women participating in prevention of mother-to-child HIV transmission programs in Kigali, Rwanda were followed until their infants were two years old. Infant anthropometrics were regularly collected. Latent class analysis was used to categorize infant growth trajectories. Multiple logistic regression was used to estimate the odds of infants belonging to each growth trajectory class. On average, this population of HEU infants had moderate linear growth faltering, but only modest faltering in weight, resulting in mean weight-for-length z-score (WLZ) above the WHO median. Mean WLZ was 0.53, and mean length-for-age z-score (LAZ) was -1.14 over the first 2 years of life. We identified four unique WLZ trajectories and seven trajectories in LAZ. Low neonatal weight-for-age and a high rate of illness increased the likelihood that infants were in the lightest WLZ-class. Shorter mothers were more likely to have infants with linear growth faltering. Female infants who were older at the end exclusive breastfeeding were more likely to be in the second tallest LAZ class. In conclusion, the current WHO recommendations of Option B+ and extended breastfeeding may induce higher WLZ and lower LAZ early in infancy. However, there is considerable heterogeneity in growth patterns which is obscured by simply analyzing average growth trends, necessitating the analysis of growth in sub-populations.

URL

http://dx.doi.org/10.1111/mcn.12776

Reference Type

Journal Article

Year Published

2019

Journal Title

Maternal & Child Nutrition

Author(s)

Lane, Charlotte E.
Bobrow, Emily A.
Ndatimana, Dieudonne
Ndayisaba, Gilles F.
Adair, Linda S.

PMCID

PMC6667835

ORCiD

Adair - 0000-0002-3670-8073
Lane, C. - 000-0002-7730-6687