Epigenetic Meta-Analysis across Three Civilian Cohorts Identifies NRG1 and HGS as Blood-Based Biomarkers for Post-Traumatic Stress Disorder

Citation

Uddin, Monica; Ratanatharathorn, Andrew; Armstrong, Don; Kuan, Pei-Fen; Aiello, Allison E.; Bromet, Evelyn J.; Galea, Sandro; Koenen, Karestan C.; Luft, Benjamin J.; & Ressler, Kerry J., et al. (2018). Epigenetic Meta-Analysis across Three Civilian Cohorts Identifies NRG1 and HGS as Blood-Based Biomarkers for Post-Traumatic Stress Disorder. Epigenomics, 10(12), 1585-1601. PMCID: PMC6331697

Abstract

AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.
MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.
RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).
CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

URL

http://dx.doi.org/10.2217/epi-2018-0049

Reference Type

Journal Article

Year Published

2018

Journal Title

Epigenomics

Author(s)

Uddin, Monica
Ratanatharathorn, Andrew
Armstrong, Don
Kuan, Pei-Fen
Aiello, Allison E.
Bromet, Evelyn J.
Galea, Sandro
Koenen, Karestan C.
Luft, Benjamin J.
Ressler, Kerry J.
Wildman, Derek E.
Nievergelt, Caroline M.
Smith, Alicia K.

PMCID

PMC6331697

ORCiD

Aiello - 0000-0001-7029-2537