Interaction between Known Risk Factors for Head and Neck Cancer and Socioeconomic Status: The Carolina Head and Neck Cancer Study

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Citation

Stanford-Moore, Gaelen; Bradshaw, Patrick T.; Weissler, Mark Christian; Zevallos, Jose P.; Brennan, Paul; Anantharaman, Devasena; Abedi-Ardekani, Behnoush; & Olshan, Andrew F. (2018). Interaction between Known Risk Factors for Head and Neck Cancer and Socioeconomic Status: The Carolina Head and Neck Cancer Study. Cancer Causes & Control, 29(9), 863-873. PMCID: PMC6133180

Abstract

Prior studies of squamous cell carcinoma of the head and neck (SCCHN) have explored the effect of socioeconomic status (SES) as an independent risk factor; however, none have investigated the interaction of known risk factors with SES. We examined this using the North Carolina Head and Neck Cancer Epidemiology Study, a population-based case-control study. Incident cases of SCCHN from North Carolina between 2002 and 2006 (n = 1,153) were identified and age, sex, and race-matched controls (n = 1,267) were selected from driver license records. SES measures included household income, educational attainment, and health insurance. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Current smoking was more strongly associated with SCCHN among those households making < $20,000/year [OR 5.11 (3.61-6.61)] compared to household incomes > $50,000/year [OR 2.47 (1.69-3.25); p interaction < 0.001]. Current drinking was more strongly associated with SCCHN in household incomes < $20,000 [OR 2.91 (2.05-3.78)] compared to > $50,000/year [1.28 (0.97-1.58); p interaction < 0.001]. Current drinkers with less than high school education or income < $20,000 had nearly threefold odds of never-drinkers in the same SES category [OR 2.91 (2.05-3.78); 2.09 (1.39-2.78), respectively]. Our results suggest that the relationship of smoking and alcohol use may be stronger among those of lower SES.

URL

http://dx.doi.org/10.1007/s10552-018-1062-8

Reference Type

Journal Article

Year Published

2018

Journal Title

Cancer Causes & Control

Author(s)

Stanford-Moore, Gaelen
Bradshaw, Patrick T.
Weissler, Mark Christian
Zevallos, Jose P.
Brennan, Paul
Anantharaman, Devasena
Abedi-Ardekani, Behnoush
Olshan, Andrew F.

PMCID

PMC6133180

ORCiD

Olshan - 0000-0001-9115-5128