Citation
Matijevic, Nena; Wu, Kenneth K.; Howard, Annie Green; Wasserman, Bruce A.; Wang, Willa Yao-Wei; Folsom, Aaron R.; & Sharrett, A. Richey (2011). Association of Blood Monocyte and Platelet Markers with Carotid Artery Characteristics: The Atherosclerosis Risk in Communities Carotid MRI Study. Cerebrovascular Diseases, 31(6), 552-558. PMCID: PMC3085521Abstract
BACKGROUND: Atherosclerosis is characterized by infiltration of inflammatory cells from circulating blood. Blood cell activation could play an important role in plaque formation.METHODS: We analyzed the relationship between blood cellular markers and quantitative measures of carotid wall components in 1,546 participants from the ARIC (Atherosclerosis Risk in Communities) Carotid MRI Study. Carotid imaging was performed using a gadolinium contrast-enhanced MRI and cellular phenotyping by flow cytometry.
RESULTS: Monocyte Toll-like receptor (TLR)-2 is associated with larger plaques, while CD14, myeloperoxidase, and TLR-4 associate with smaller. Platelet CD40L is associated with smaller plaques and thinner caps, while P-selectin is associated with smaller core size.
CONCLUSIONS: Blood cell activation is significantly associated with atherosclerotic changes of the carotid wall.
URL
http://dx.doi.org/10.1159/000324389Reference Type
Journal ArticleYear Published
2011Journal Title
Cerebrovascular DiseasesAuthor(s)
Matijevic, NenaWu, Kenneth K.
Howard, Annie Green
Wasserman, Bruce A.
Wang, Willa Yao-Wei
Folsom, Aaron R.
Sharrett, A. Richey