Refining the Accuracy of Validated Target Identification through Coding Variant Fine-Mapping in Type 2 Diabetes

Citation

Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M.; Zhao, Wei; Robertson, Neil R.; Chu, Audrey Y.; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; & Rayner, Nigel W., et al. (2018). Refining the Accuracy of Validated Target Identification through Coding Variant Fine-Mapping in Type 2 Diabetes. Nature Genetics, 50(4), 559-571. PMCID: PMC5898373

Abstract

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 x 10(-7)); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-frequency variants: even for these, effect sizes are modest (odds ratio

URL

http://dx.doi.org/10.1038/s41588-018-0084-1

Reference Type

Journal Article

Year Published

2018

Journal Title

Nature Genetics

Author(s)

Mahajan, Anubha
Wessel, Jennifer
Willems, Sara M.
Zhao, Wei
Robertson, Neil R.
Chu, Audrey Y.
Gan, Wei
Kitajima, Hidetoshi
Taliun, Daniel
Rayner, Nigel W.
Guo, Xiuqing
Lu, Yingchang
Li, Man
Jensen, Richard A.
Hu, Yao
Huo, Shaofeng
Lohman, Kurt K.
Zhang, Weihua
Cook, James P.
Prins, Bram Peter
Flannick, Jason
Grarup, Niels
Trubetskoy, Vassily Vladimirovich
Kravic, Jasmina
Kim, Young Jin
Rybin, Denis
Yaghootkar, Hanieh
Muller-Nurasyid, Martina
Meidtner, Karina
Li-Gao, Ruifang
Varga, Tibor V.
Marten, Jonathan
Li, Jin
Smith, Albert V.
An, Ping
Ligthart, Symen
Gustafsson, Stefan
Malerba, Giovanni
Demirkan, Ayse
Tajes, Juan Fernandez
Steinthorsdottir, Valgerdur
Wuttke, Matthias
Lecoeur, Cecile
Preuss, Michael H.
Bielak, Lawrence F.
Graff, Mariaelisa
Highland, Heather M.
Justice, Anne E.
Liu, Dajiang J.
Marouli, Eirini
Peloso, Gina M.
Warren, Helen R.
ExomeBP Consortium,
MAGIC Consortium,
GIANT Consortium,
Afaq, Saima
Afzal, Shoaib
Ahlqvist, Emma
Almgren, Peter
Amin, Najaf
Bang, Lia B.
Bertoni, Alain G.
Bombieri, Cristina
Bork-Jensen, Jette
Brandslund, Ivan
Brody, Jennifer A.
Burtt, Noel P.
Canouil, Mickael
Chen, Yii-Der Ida
Cho, Yoon Shin
Christensen, Cramer
Eastwood, Sophie V.
Eckardt, Kai-Uwe
Fischer, Krista
Gambaro, Giovanni
Giedraitis, Vilmantas
Grove, Megan L.
de Haan, Hugoline G.
Hackinger, Sophie
Hai, Yang
Han, Sohee
Tybjaerg-Hansen, Anne
Hivert, Marie-France
Isomaa, Bo
Jager, Susanne
Jorgensen, Marit E.
Jorgensen, Torben
Karajamaki, Annemari
Kim, Bong-Jo
Kim, Sung Soo
Koistinen, Heikki A.
Kovacs, Peter
Kriebel, Jennifer
Kronenberg, Florian
Lall, Kristi
Lange, Leslie A.
Lee, Jung-Jin
Lehne, Benjamin
Li, Huaixing
Lin, Keng-Hung
Linneberg, Allan
Liu, Ching-Ti
Liu, Jun
Loh, Marie
Magi, Reedik
Mamakou, Vasiliki
McKean-Cowdin, Roberta
Nadkarni, Girish
Neville, Matt
Nielsen, Sune F.
Ntalla, Ioanna
Peyser, Patricia A.
Rathmann, Wolfgang
Rice, Kenneth M.
Rich, Stephen S.
Rode, Line
Rolandsson, Olov
Schonherr, Sebastian
Selvin, Elizabeth
Small, Kerrin S.
Stancakova, Alena
Surendran, Praveen
Taylor, Kent D.
Teslovich, Tanya M.
Thorand, Barbara
Thorleifsson, Gudmar
Tin, Adrienne
Tonjes, Anke
Varbo, Anette
Witte, Daniel R.
Wood, Andrew R.
Yajnik, Pranav
Yao, Jie
Yengo, Loic
Young, Robin D.
Amouyel, Philippe
Boeing, Heiner
Boerwinkle, Eric A.
Bottinger, Erwin P.
Chowdhury, Rajiv
Collins, Francis S.
Dedoussis, George
Dehghan, Abbas
Deloukas, Panos
Ferrario, Marco M.
Ferrieres, Jean
Florez, Jose C.
Frossard, Philippe
Gudnason, Vilmundur G.
Harris, Tamara B.
Heckbert, Susan R.
Howson, Joanna M. M.
Ingelsson, Martin
Kathiresan, Sekar
Kee, Frank
Kuusisto, Johanna
Langenberg, Claudia
Launer, Lenore J.
Lindgren, Cecilia M.
Mannisto, Satu
Meitinger, Thomas
Melander, Olle
Mohlke, Karen L.
Moitry, Marie
Morris, Andrew D.
Murray, Alison D.
de Mutsert, Renee
Orho-Melander, Marju
Owen, Katharine R.
Perola, Markus
Peters, Annette
Province, Michael A.
Rasheed, Asif
Ridker, Paul M.
Rivadeneira, Fernando
Rosendaal, Frits R.
Rosengren, Anders H.
Salomaa, Veikko
Sheu, Wayne Huey-Herng
Sladek, Rob
Smith, Blair H.
Strauch, Konstantin
Uitterlinden, Andre G.
Varma, Rohit
Willer, Cristen J.
Bluher, Matthias
Butterworth, Adam S.
Chambers, John C.
Chasman, Daniel I.
Danesh, John
van Duijn, Cornelia M.
Dupuis, Josee
Franco, Oscar H.
Franks, Paul W.
Froguel, Philippe
Grallert, Harald
Groop, Leif C.
Han, Bok-Ghee
Hansen, Torben
Hattersley, Andrew T.
Hayward, Caroline
Ingelsson, Erik
Kardia, Sharon L. R.
Karpe, Fredrik
Kooner, Jaspal Singh S.
Kottgen, Anna
Kuulasmaa, Kari
Laakso, Markku
Lin, Xu
Lind, Lars
Liu, Yongmei
Loos, Ruth J. F.
Marchini, Jonathan
Metspalu, Andres
Mook-Kanamori, Dennis O.
Nordestgaard, Borge G.
Palmer, Colin N. A.
Pankow, James S.
Pedersen, Oluf
Psaty, Bruce M.
Rauramaa, Rainer
Sattar, Naveed
Schulze, Matthias B.
Soranzo, Nicole
Spector, Timothy D.
Stefansson, Kari
Stumvoll, Michael
Thorsteinsdottir, Unnur
Tuomi, Tiinamaija
Tuomilehto, Jaakko
Wareham, Nicholas J.
Wilson, James G.
Zeggini, Eleftheria
Scott, Robert A.
Barroso, Ines
Frayling, Timothy M.
Goodarzi, Mark O.
Meigs, James B.
Boehnke, Michael
Saleheen, Danish
Morris, Andrew P.
Rotter, Jerome I.
McCarthy, Mark I.

PMCID

PMC5898373

ORCiD

Highland - 000-0002-3583-8239
Graff - 0000-0001-6380-1735