Interaction between Polyunsaturated Fatty Acids and Genetic Variants in Relation to Breast Cancer Incidence

Citation

Khankari, Nikhil K.; Bradshaw, Patrick T.; Steck, Susan E.; He, Ka; Olshan, Andrew F.; Ahn, Jiyoung; Terry, Mary Beth; Crew, Katherine D.; Teitelbaum, Susan L.; & Neugut, Alfred I., et al. (2016). Interaction between Polyunsaturated Fatty Acids and Genetic Variants in Relation to Breast Cancer Incidence. Journal of Cancer Epidemiology and Prevention, 1(1), 2. PMCID: PMC5621474

Abstract

Higher intake of omega-3 relative to omega-6 polyunsaturated fatty acids (PUFAs) may reduce breast carcinogenesis via different metabolic pathways. The PUFA-breast cancer association remains inconclusive, thus, we hypothesized that interactions between the ratio of dietary omega-3:omega-6 intake and polymorphisms from PUFA-related metabolic pathways would help elucidate an association. Utilizing resources from the Long Island Breast Cancer Study Project, a population-based case-control study (n=1035 cases/1075 controls), we examined interactions between omega-3:omega-6 ratio and 18 polymorphisms of 15 genes. Compared to the putative lowest risk group (high omega-3:omega-6,low-risk FASL rs763110 CT/TT genotype), the odds ratio (OR) for breast cancer from unconditional logistic regression models was weakly increased for other exposure-genotype combinations (high omega-3:omega-6,high-risk FASL CC genotype, OR=1.18,95% confidence interval(CI)=0.90,1.53; low omega-3:omega-6,CT/TT genotype, OR=1.35,95%CI=1.09,1.66); but was approximately null for the putative highest risk group (low omega-3:omega-6,CC genotype; OR=1.06,95%CI=0.81,1.38). We observed an interaction between the omega-3:omega-6 ratio and FASL rs763110 on the additive scale [Relative Excess Risk Due to Interaction(RERI)=-0.47, 95%CI=-0.92,-0.02]. Interactions with other polymorphisms considered were not evident. Our findings suggest that the PUFA-breast cancer association may be modified by FASL. However, additional research is needed given this interaction may be due to chance and is inconsistent with our a priori biologic hypothesis.

URL

http://www.imedpub.com/articles/interaction-between-polyunsaturated-fatty-acids-and-genetic-variants-in-relation-to-breast-cancer-incidence.php?aid=18160

Reference Type

Journal Article

Year Published

2016

Journal Title

Journal of Cancer Epidemiology and Prevention

Author(s)

Khankari, Nikhil K.
Bradshaw, Patrick T.
Steck, Susan E.
He, Ka
Olshan, Andrew F.
Ahn, Jiyoung
Terry, Mary Beth
Crew, Katherine D.
Teitelbaum, Susan L.
Neugut, Alfred I.
Santella, Regina M.
Gammon, Marilie D.

PMCID

PMC5621474

ORCiD

Olshan - 0000-0001-9115-5128