Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations

Citation

Wiegand, Samantha L.; Swortwood, Madeleine J.; Huestis, Marilyn A.; Thorp, John M., Jr.; Jones, Hendreé E.; & Vora, Neeta L. (2016). Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations. American Journal of Perinatology, 6(4), e385-90. PMCID: PMC5120978

Abstract

Objective: To quantify naloxone and metabolite concentrations in newborns prenatally exposed to sublingual buprenorphine/naloxone and to correlate neonatal and maternal metabolite concentrations.
Methods: This is a prospective observational cohort study. Eleven pregnant women treated for opioid use disorder with sublingual buprenorphine/naloxone were enrolled. Maternal and newborn blood was collected and analyzed for naloxone, buprenorphine, and metabolites via liquid chromatography tandem mass spectrometry. Descriptive statistics and correlation coefficients were utilized to analyze data.
Results: Maternal daily naloxone and buprenorphine doses were 1 to 5 mg and 4 to 20 mg, respectively; the mean (standard deviation) time from medication until delivery was 9.9 (4.3) hours. Naloxone was below the limits of quantification (LOQ) in five infants and six mothers with a range of less than LOQ to 0.3

URL

http://dx.doi.org/10.1055/s-0036-1593993

Reference Type

Journal Article

Year Published

2016

Journal Title

American Journal of Perinatology

Author(s)

Wiegand, Samantha L.
Swortwood, Madeleine J.
Huestis, Marilyn A.
Thorp, John M., Jr.
Jones, Hendreé E.
Vora, Neeta L.

PMCID

PMC5120978

ORCiD

Thorp - 0000-0002-9307-6690